Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression

D. Ish-Horowicz, S. M. Pinchin, P. W. Ingham, H. Gyurkovics

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Inappropriate expression of the Drosophila pair-rule gene, fushi tarazu (ftz), causes cuticular pattern deletions apparently complementary to those in ftz larvae. We show that the two patterns actually originate similarly, in both cases affecting the even-numbered parasegmental boundaries. The reciprocal cuticular patterns derive from differing patterns of selector gene expression (homoeotic transformations). The primary effect of ectopic ftz activity is to broaden ftz domains by autocatalytic activation of endogenous ftz expression in an additional anterior cell. This activates engrailed (en) and represses wingless (wg) expression, consistent with their proposed combinatorial control by ftz (and other pair-rule genes) to define parasegmental primordia. We propose that the anterior margin of each ftz stripe is normally defined by the posterior even-skipped (eve) boundary.

Original languageEnglish
Pages (from-to)223-232
Number of pages10
JournalCell
Volume57
Issue number2
DOIs
Publication statusPublished - Apr 21 1989

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Genes
Chemical activation
Gene expression
Drosophila
Larva
Gene Expression

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression. / Ish-Horowicz, D.; Pinchin, S. M.; Ingham, P. W.; Gyurkovics, H.

In: Cell, Vol. 57, No. 2, 21.04.1989, p. 223-232.

Research output: Contribution to journalArticle

Ish-Horowicz, D. ; Pinchin, S. M. ; Ingham, P. W. ; Gyurkovics, H. / Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression. In: Cell. 1989 ; Vol. 57, No. 2. pp. 223-232.
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