Autoantibody against liver cell membrane and killer cell activity in chronic liver diseases.

R. Schnabel, L. Dalmi, S. Sipka, M. Bokor, G. Malatinszky, T. Garam

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Abstract

The aim of our present study was to examine the ADCC reaction against liver cell in various chronic liver diseases on the basis of indirect evidence. Forty-nine liver patients and one hundred and twenty-three healthy controls were examined. Anti-LSP autoantibody was determined on rat liver membrane by using the indirect immunofluorescent method. On the other hand, Killer-cell activity against human erythrocyte target cells was established in the lymphocytes of peripheral blood. Anti-LSP autoantibodies were demonstrated in seven patients and were associated with the high Killer-cell activity in six cases. Specific ADCC reaction to liver cell membrane can be assumed if anti-LSP autoantibody presence is topped with increased Killer-cell activity.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalActa medica Hungarica
Volume48
Issue number1-2
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Medicine(all)

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Schnabel, R., Dalmi, L., Sipka, S., Bokor, M., Malatinszky, G., & Garam, T. (1991). Autoantibody against liver cell membrane and killer cell activity in chronic liver diseases. Acta medica Hungarica, 48(1-2), 23-31.