Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome

Mihály Józsi, Stefanie Reuter, Pilar Nozal, Margarita López-Trascasa, Pilar Sánchez-Corral, Z. Prohászka, Barbara Uzonyi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The alternative pathway of complement is implicated in the pathogenesis of several renal diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other forms of C3 glomerulopathy. The underlying complement defects include genetic and/or acquired factors, the latter in the form of autoantibodies. Because the autoimmune forms require a specific treatment, in part different from that of the genetic forms, it is important to detect the autoantibodies as soon as possible and understand their characteristics. In this overview, we summarize the types of anti-complement autoantibodies detected in such diseases, i.e. autoantibodies to factor H, factor I, C3b, factor B and those against the C3 convertases (C3 nephritic factor and C4 nephritic factor). We draw attention to newly described autoantibodies and their characteristics, and highlight similarities and differences in the autoimmune forms of these diseases.

Original languageEnglish
Pages (from-to)163-171
Number of pages9
JournalImmunology Letters
Volume160
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Autoantibodies
Complement C3 Nephritic Factor
Complement C3-C5 Convertases
Membranoproliferative Glomerulonephritis
Alternative Complement Pathway
Complement Factor H
Autoimmune Diseases
Atypical Hemolytic Uremic Syndrome
Kidney

Keywords

  • Atypical hemolytic uremic syndrome
  • Autoantibodies
  • C3 convertase
  • C3 glomerulopathy
  • C3 nephritic factor
  • Complement regulation
  • Factor B
  • Factor H
  • Kidney disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Józsi, M., Reuter, S., Nozal, P., López-Trascasa, M., Sánchez-Corral, P., Prohászka, Z., & Uzonyi, B. (2014). Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. Immunology Letters, 160(2), 163-171. https://doi.org/10.1016/j.imlet.2014.01.014

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. / Józsi, Mihály; Reuter, Stefanie; Nozal, Pilar; López-Trascasa, Margarita; Sánchez-Corral, Pilar; Prohászka, Z.; Uzonyi, Barbara.

In: Immunology Letters, Vol. 160, No. 2, 2014, p. 163-171.

Research output: Contribution to journalArticle

Józsi, M, Reuter, S, Nozal, P, López-Trascasa, M, Sánchez-Corral, P, Prohászka, Z & Uzonyi, B 2014, 'Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome', Immunology Letters, vol. 160, no. 2, pp. 163-171. https://doi.org/10.1016/j.imlet.2014.01.014
Józsi, Mihály ; Reuter, Stefanie ; Nozal, Pilar ; López-Trascasa, Margarita ; Sánchez-Corral, Pilar ; Prohászka, Z. ; Uzonyi, Barbara. / Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. In: Immunology Letters. 2014 ; Vol. 160, No. 2. pp. 163-171.
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