Autoantibodies to alfa-fodrin in patients with Hashimoto thyroiditis and Sjögren's syndrome: Possible markers for a common secretory disorder

Antonia Szanto, I. Csípő, Ildiko Horvath, Edit Biro, Peter Szodoray, M. Zeher

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Presence of autoantibodies to alfa-fodrin was investigated in patients with Sjögren's syndrome (n = 61), Hashimoto thyroiditis (n = 27), Sjögren's syndrome associated with Hashimoto thyroiditis (n = 31) and in healthy persons (n = 77). In each group, level of alfa-fodrin antibodies was higher than in the controls. There was no significant difference in their presence either between patients with Hashimoto thyroiditis with or without Sjögren's syndrome, or-in IgA isotype-between Sjögren's and Hashimoto thyroiditis patients. Correlation was found between the level of IgG alfa-fodrin and anti-thyroglobulin antibodies. Based on these findings, fodrin can be associated with both endocrine and exocrine glandular secretion. Antibodies to alfa-fodrin might have a role in the pathogenesis of Hashimoto thyroiditis concerning the "final common effectory pathway", secretion. Alfa-fodrin antibodies can be good markers of secretory disorders. Assessment of these autoantibodies might help the diagnosis and follow-up of patients with impaired secretory capability of not only autoimmune origin.

Original languageEnglish
Pages (from-to)1169-1172
Number of pages4
JournalRheumatology International
Volume28
Issue number11
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Hashimoto Disease
Autoantibodies
Antibodies
Secretory Pathway
Immunoglobulin A
fodrin
Immunoglobulin G

Keywords

  • Alfa-fodrin
  • Autoimmune thyroid disease
  • Hashimoto thyroiditis
  • Secretion
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Rheumatology

Cite this

Autoantibodies to alfa-fodrin in patients with Hashimoto thyroiditis and Sjögren's syndrome : Possible markers for a common secretory disorder. / Szanto, Antonia; Csípő, I.; Horvath, Ildiko; Biro, Edit; Szodoray, Peter; Zeher, M.

In: Rheumatology International, Vol. 28, No. 11, 09.2008, p. 1169-1172.

Research output: Contribution to journalArticle

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