Autistic Traits in Neurotypical Adults: Correlates of Graph Theoretical Functional Network Topology and White Matter Anisotropy Patterns

Andras Jakab, Monika Beres, Ervin Berenyi, M. Emri, Tamas Spisak, Sandor Attila Kis, Anita Szeman-Nagy, P. Molnár

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Attempts to explicate the neural abnormalities behind autism spectrum disorders frequently revealed impaired brain connectivity, yet our knowledge is limited about the alterations linked with autistic traits in the non-clinical population. In our study, we aimed at exploring the neural correlates of dimensional autistic traits using a dual approach of diffusion tensor imaging (DTI) and graph theoretical analysis of resting state functional MRI data. Subjects were sampled from a public neuroimaging dataset of healthy volunteers. Inclusion criteria were adult age (age: 18-65), availability of DTI and resting state functional acquisitions and psychological evaluation including the Social Responsiveness Scale (SRS) and Autistic Spectrum Screening Questionnaire (ASSQ). The final subject cohort consisted of 127 neurotypicals. Global brain network structure was described by graph theoretical parameters: global and average local efficiency. Regional topology was characterized by degree and efficiency. We provided measurements for diffusion anisotropy. The association between autistic traits and the neuroimaging findings was studied using a general linear model analysis, controlling for the effects of age, gender and IQ profile. Significant negative correlation was found between the degree and efficiency of the right posterior cingulate cortex and autistic traits, measured by the combination of ASSQ and SRS scores. Autistic phenotype was associated with the decrease of whole-brain local efficiency. Reduction of diffusion anisotropy was found bilaterally in the temporal fusiform and parahippocampal gyri. Numerous models describe the autistic brain connectome to be dominated by reduced long-range connections and excessive short-range fibers. Our finding of decreased efficiency supports this hypothesis although the only prominent effect was seen in the posterior limbic lobe, which is known to act as a connector hub. The neural correlates of the autistic trait in neurotypicals showed only limited similarities to the reported findings in clinical populations with low functioning autism.

Original languageEnglish
Article numbere60982
JournalPLoS One
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 5 2013

Fingerprint

Anisotropy
topology
Topology
Brain
brain
Diffusion Tensor Imaging
Diffusion tensor imaging
Neuroimaging
Temporal Lobe
Connectome
questionnaires
image analysis
screening
Screening
Parahippocampal Gyrus
Gyrus Cinguli
Autistic Disorder
Population
volunteers
Linear Models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Autistic Traits in Neurotypical Adults : Correlates of Graph Theoretical Functional Network Topology and White Matter Anisotropy Patterns. / Jakab, Andras; Beres, Monika; Berenyi, Ervin; Emri, M.; Spisak, Tamas; Kis, Sandor Attila; Szeman-Nagy, Anita; Molnár, P.

In: PLoS One, Vol. 8, No. 4, e60982, 05.04.2013.

Research output: Contribution to journalArticle

Jakab, Andras ; Beres, Monika ; Berenyi, Ervin ; Emri, M. ; Spisak, Tamas ; Kis, Sandor Attila ; Szeman-Nagy, Anita ; Molnár, P. / Autistic Traits in Neurotypical Adults : Correlates of Graph Theoretical Functional Network Topology and White Matter Anisotropy Patterns. In: PLoS One. 2013 ; Vol. 8, No. 4.
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