Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex

Charlotte Tye, Teresa Farroni, A. Volein, Evelyne Mercure, Leslie Tucker, Mark H. Johnson, Patrick F. Bolton

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Autism spectrum disorder (ASD) is a common and highly heritable neurodevelopmental disorder that is likely to be the outcome of complex aetiological mechanisms. One strategy to provide insight is to study ASD within tuberous sclerosis complex (TSC), a rare disorder with a high incidence of ASD, but for which the genetic cause is determined. Individuals with ASD consistently demonstrate face processing impairments, but these have not been examined in adults with TSC using event-related potentials (ERPs) that are able to capture distinct temporal stages of processing. Methods: For adults with TSC (n = 14), 6 of which had a diagnosis of ASD, and control adults (n = 13) passively viewed upright and inverted human faces with direct or averted gaze, with concurrent EEG recording. Amplitude and latency of the P1 and N170 ERPs were measured. Results: Individuals with TSC + ASD exhibited longer N170 latencies to faces compared to typical adults. Typical adults and adults with TSC-only exhibited longer N170 latency to inverted versus upright faces, whereas individuals with TSC + ASD did not show latency differences according to face orientation. In addition, individuals with TSC + ASD showed increased N170 latency to averted compared to direct gaze, which was not demonstrated in typical adults. A reduced lateralization was shown for the TSC + ASD groups on P1 and N170 amplitude. Conclusions: The findings suggest that individuals with TSC + ASD may have similar electrophysiological abnormalities to idiopathic ASD and are suggestive of developmental delay. Identifying brain-based markers of ASD that are similar in TSC and idiopathic cases is likely to help elucidate the risk pathways to ASD.

Original languageEnglish
Article number33
JournalJournal of Neurodevelopmental Disorders
Volume7
Issue number1
DOIs
Publication statusPublished - Oct 7 2015

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Tuberous Sclerosis
Autistic Disorder
Evoked Potentials
Autism Spectrum Disorder
Electroencephalography

Keywords

  • Autism spectrum disorder
  • ERP
  • Face
  • Gaze
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cognitive Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cite this

Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex. / Tye, Charlotte; Farroni, Teresa; Volein, A.; Mercure, Evelyne; Tucker, Leslie; Johnson, Mark H.; Bolton, Patrick F.

In: Journal of Neurodevelopmental Disorders, Vol. 7, No. 1, 33, 07.10.2015.

Research output: Contribution to journalArticle

Tye, Charlotte ; Farroni, Teresa ; Volein, A. ; Mercure, Evelyne ; Tucker, Leslie ; Johnson, Mark H. ; Bolton, Patrick F. / Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex. In: Journal of Neurodevelopmental Disorders. 2015 ; Vol. 7, No. 1.
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