GESTEIGERTER OXIDATIVER METABOLISMUS VON ALVEOLARMAKROPHAGEN (AM) BEI IDIOPATHISCHER FIBROSIERENDER ALVEOLITIS (IPF)

Translated title of the contribution: Augmented oxidative metabolism of alveolar macrophages (AM) in idiopathic fibrosing alveolitis (IPF)

H. Steppling, M. Nagel, J. Strausz, J. Muller-Quernheim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The results of the present investigation show that, in IPF, alveolar macrophages are preactivated, and are capable, both spontaneously and also after cellular stimulation with a variety of stimulants, of producing appreciably more cytotoxic oxygen metabolites as compared with alveolar macrophages from healthy control subjects. A striking finding is the fact that the production of oxidants following stimulation with the complement factors C3a-C5a and aggregated IgG is appreciably lower than following stimulation with PMA or zymosan. This might be evidence in support of the theory that the alveolar macrophages in IPF are activated by immune complexes.

Original languageGerman
Pages (from-to)303-305
Number of pages3
JournalPneumologie, Sonderheft
Volume44
Issue number1
Publication statusPublished - 1990

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Pulmonary Fibrosis
Alveolar Macrophages
Complement C3a
Zymosan
Antigen-Antibody Complex
Oxidants
Healthy Volunteers
Immunoglobulin G
Oxygen

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

GESTEIGERTER OXIDATIVER METABOLISMUS VON ALVEOLARMAKROPHAGEN (AM) BEI IDIOPATHISCHER FIBROSIERENDER ALVEOLITIS (IPF). / Steppling, H.; Nagel, M.; Strausz, J.; Muller-Quernheim, J.

In: Pneumologie, Sonderheft, Vol. 44, No. 1, 1990, p. 303-305.

Research output: Contribution to journalArticle

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