Auditory evoked potentials reflect serotonergic neuronal activity - A study in behaving cats administered drugs acting on 5-HT(1A) autoreceptors in the dorsal raphe nucleus

Georg Juckel, Ulrich Hegerl, Márk Molnár, Valéria Csépe, George Karmos

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121 Citations (Scopus)

Abstract

A valid indicator of central serotonergic neurotransmission would be useful for various diagnostic and psychopharmacological purposes in psychiatry. However, known peripheral serotonergic measures only partially reflect serotonergic function in the brain. Previous findings suggest that the intensity dependence of auditory evoked potentials (AEPs) is closely related to central serotonergic activity. The present study examines the effects of microinjection of a 5-HT(1A) agonist (8-OH-DPAT) and a 5-HT(1A) antagonist (spiperone) into the dorsal raphe nucleus (DRN) on AEP recorded epidurally from the primary and secondary auditory cortex in behaving cats. We found a stronger intensity dependence only of AEP from the primary auditory cortex after 8-OH-DPAT, which inhibits the firing rate of serotonergic DRN neurons, and a weaker intensity dependence after spiperone, which increases serotonergic cell firing, as compared to baseline measurements. These results demonstrate that the intensity dependence of AEP is inversely related to serotonergic neuronal activity and that it may be a promising tool for assessing central serotonergic function in humans (e.g., identifying patients with low serotonergic neurotransmission).

Original languageEnglish
Pages (from-to)710-716
Number of pages7
JournalNeuropsychopharmacology
Volume21
Issue number6
DOIs
Publication statusPublished - Dec 1999

Fingerprint

Autoreceptors
Auditory Evoked Potentials
Serotonin
Cats
Spiperone
8-Hydroxy-2-(di-n-propylamino)tetralin
Auditory Cortex
Synaptic Transmission
Pharmaceutical Preparations
Serotonin Receptor Agonists
Serotonin Antagonists
Microinjections
Psychiatry
Neurons
Dorsal Raphe Nucleus
Brain
hydroxide ion

Keywords

  • 5-HT(1A) receptor
  • Auditory cortex
  • Auditory evoked potentials
  • Dorsal raphe nucleus
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

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AU - Csépe, Valéria

AU - Karmos, George

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