Atypical teratoid/rhabdoid tumor arising in a malignant glioma

Barbara Bozzai, Martin Hasselblatt, Eszter Turányi, Michael C. Frühwald, Reiner Siebert, Susanne Bens, Reinhard Schneppenheim, Marcel Kool, Gábor Stelczer, T. Hortobágyi, P. Hauser

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.

Original languageEnglish
JournalPediatric Blood and Cancer
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Glioma
temozolomide
Neoplasms
Glioblastoma
Brain Neoplasms
Biopsy
Recurrence
Atypical Teratoid Tumor
Typical Teratoid Rhabdoid Tumor

Keywords

  • Atypical teratoid/rhabdoid tumor
  • Glioblastoma
  • Irradiation
  • Pleomorphic xanthoastrocytoma
  • Temozolomide
  • Therapy-induced secondary tumor

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Bozzai, B., Hasselblatt, M., Turányi, E., Frühwald, M. C., Siebert, R., Bens, S., ... Hauser, P. (Accepted/In press). Atypical teratoid/rhabdoid tumor arising in a malignant glioma. Pediatric Blood and Cancer. https://doi.org/10.1002/pbc.26173

Atypical teratoid/rhabdoid tumor arising in a malignant glioma. / Bozzai, Barbara; Hasselblatt, Martin; Turányi, Eszter; Frühwald, Michael C.; Siebert, Reiner; Bens, Susanne; Schneppenheim, Reinhard; Kool, Marcel; Stelczer, Gábor; Hortobágyi, T.; Hauser, P.

In: Pediatric Blood and Cancer, 2016.

Research output: Contribution to journalArticle

Bozzai, B, Hasselblatt, M, Turányi, E, Frühwald, MC, Siebert, R, Bens, S, Schneppenheim, R, Kool, M, Stelczer, G, Hortobágyi, T & Hauser, P 2016, 'Atypical teratoid/rhabdoid tumor arising in a malignant glioma', Pediatric Blood and Cancer. https://doi.org/10.1002/pbc.26173
Bozzai B, Hasselblatt M, Turányi E, Frühwald MC, Siebert R, Bens S et al. Atypical teratoid/rhabdoid tumor arising in a malignant glioma. Pediatric Blood and Cancer. 2016. https://doi.org/10.1002/pbc.26173
Bozzai, Barbara ; Hasselblatt, Martin ; Turányi, Eszter ; Frühwald, Michael C. ; Siebert, Reiner ; Bens, Susanne ; Schneppenheim, Reinhard ; Kool, Marcel ; Stelczer, Gábor ; Hortobágyi, T. ; Hauser, P. / Atypical teratoid/rhabdoid tumor arising in a malignant glioma. In: Pediatric Blood and Cancer. 2016.
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