Atypical teratoid/rhabdoid tumor arising in a malignant glioma

Barbara Bozzai, Martin Hasselblatt, Eszter Turányi, Michael C. Frühwald, Reiner Siebert, Susanne Bens, Reinhard Schneppenheim, Marcel Kool, Gábor Stelczer, T. Hortobágyi, P. Hauser

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.

Original languageEnglish
JournalPediatric Blood and Cancer
DOIs
Publication statusAccepted/In press - 2016

Keywords

  • Atypical teratoid/rhabdoid tumor
  • Glioblastoma
  • Irradiation
  • Pleomorphic xanthoastrocytoma
  • Temozolomide
  • Therapy-induced secondary tumor

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Fingerprint Dive into the research topics of 'Atypical teratoid/rhabdoid tumor arising in a malignant glioma'. Together they form a unique fingerprint.

  • Cite this

    Bozzai, B., Hasselblatt, M., Turányi, E., Frühwald, M. C., Siebert, R., Bens, S., Schneppenheim, R., Kool, M., Stelczer, G., Hortobágyi, T., & Hauser, P. (Accepted/In press). Atypical teratoid/rhabdoid tumor arising in a malignant glioma. Pediatric Blood and Cancer. https://doi.org/10.1002/pbc.26173