Attenuation of morphine tolerance and dependence by α-melanocyte stimulating hormone (α-MSH)

Jòzsef I. Szèkely, Erzsèbet Miglècz, Zsuzsa Dunai-Kovàcs, Istvàn Tarnawa, A. Rónai, L. Gráf, Sàndor Bajusz

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Abstract

Repeated administration of morphine resulted in significant reduction of its analgesic potency. If 0.1 mg/kg α-MSH was coadministered, the tolerance development was attenuated, 1 mg/kg MIF (MSH release inhibiting factor), given simultaneously with morphine, did not affect tolerance. Injecting, however, MIF 1 hour prior to the daily opiate treatment resulted in accelerated development of tolerance supposedly by lowering the plasma α-MSH level at the time of morphine administration. Of the morphine abstinence symptoms the naloxone-induced jumping in morphine pretreated mice could not be modified either by α-MSH coadministration or by MIF pretreament, but the withdrawal body weight loss was found to be diminished by the former and increased by the latter peptide. The possible role of α-MSH in preventing the development of tolerance to the analgesic effect of endogenous opioid peptides is discussed.

Original languageEnglish
Pages (from-to)1931-1938
Number of pages8
JournalLife Sciences
Volume24
Issue number21
DOIs
Publication statusPublished - May 21 1979

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Morphine Dependence
Melanocyte-Stimulating Hormones
Morphine
MSH Release-Inhibiting Hormone
Analgesics
Opiate Alkaloids
Opioid Peptides
Naloxone
Weight Loss
Body Weight
Plasmas
Peptides

ASJC Scopus subject areas

  • Pharmacology

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Attenuation of morphine tolerance and dependence by α-melanocyte stimulating hormone (α-MSH). / Szèkely, Jòzsef I.; Miglècz, Erzsèbet; Dunai-Kovàcs, Zsuzsa; Tarnawa, Istvàn; Rónai, A.; Gráf, L.; Bajusz, Sàndor.

In: Life Sciences, Vol. 24, No. 21, 21.05.1979, p. 1931-1938.

Research output: Contribution to journalArticle

Szèkely, Jòzsef I. ; Miglècz, Erzsèbet ; Dunai-Kovàcs, Zsuzsa ; Tarnawa, Istvàn ; Rónai, A. ; Gráf, L. ; Bajusz, Sàndor. / Attenuation of morphine tolerance and dependence by α-melanocyte stimulating hormone (α-MSH). In: Life Sciences. 1979 ; Vol. 24, No. 21. pp. 1931-1938.
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