Attenuation of isoproterenol-mediated vasodilatation in blacks

Steven R. Goldsmith, William Dachman, Zoltan Vajo, Haider Zafar, Peter Kotanko, Falko Skrabal, Chim C. Lang, C. Michael Stein, Alastair J.j. Wood

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Abstract

To the Editor: The study by Lang and colleagues (July 20 issue)1 is provocative but lacks two important control observations. First, as compared with the white subjects, the black subjects had markedly attenuated forearm blood-flow responses to isoproterenol yet similar increases in regional norepinephrine spillover. Hyperresponsiveness to the α-adrenergic effects of endogenous norepinephrine is therefore at least as likely an explanation of the findings as hyporesponsiveness to β-adrenergic stimulation by isoproterenol. No mention is made of this possibility; a direct infusion of norepinephrine or phenylephrine would easily settle the issue. Second, since regional norepinephrine spillover is heavily dependent on blood.

Original languageEnglish
Pages (from-to)1502-1503
Number of pages2
JournalNew England Journal of Medicine
Volume333
Issue number22
DOIs
Publication statusPublished - Nov 30 1995

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Goldsmith, S. R., Dachman, W., Vajo, Z., Zafar, H., Kotanko, P., Skrabal, F., Lang, C. C., Stein, C. M., & Wood, A. J. J. (1995). Attenuation of isoproterenol-mediated vasodilatation in blacks. New England Journal of Medicine, 333(22), 1502-1503. https://doi.org/10.1056/NEJM199511303332212