Attenuation of Helicobacter pylori endotoxin-provoked rat intestinal inflammation by selective inhibition of the inducible nitric oxide synthase

Zoltán Szepes, József Kiss, Dominique Lamarque, Anthony P. Moran, János Nemcsik, E. Morschl, F. László, Brendan J R Whittle

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied the actions of purified Helicobacter pylori endotoxin (3 mg kg-1, i.v.) on rat intestinal vascular permeability (assessed by the radiolabelled human serum albumin leakage technique) and on nitric oxide synthase induction (assessed by the citrulline assay) 4 h later. We found increased albumin leakage and expression of the inducible nitric oxide synthase in jejunum and colon, effects reversed by a selective inducible nitric oxide synthase inhibitor N-(8-(aminomethyl)benzyl)-acetamidine (1400W; 0.2-1 mg kg-1, s.c., concurrently with endotoxin). Thus, H. pylori endotoxin seems to be capable of provoking an inflammatory response in the rat intestinal tissue. Systemic liberation of H. pylori endotoxin might possibly attenuate jejunal and colonic mucosal barrier function, a process mediated by the expression of the inducible nitric oxide synthase.

Original languageEnglish
Pages (from-to)453-455
Number of pages3
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - 2001

Fingerprint

Nitric Oxide Synthase Type II
Endotoxins
Helicobacter pylori
Inflammation
Citrulline
Capillary Permeability
Jejunum
Serum Albumin
Nitric Oxide Synthase
Albumins
Colon

Keywords

  • Helicobacter pylori endotoxin
  • Inducible nitric oxide synthase
  • Intestinal inflammation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

Attenuation of Helicobacter pylori endotoxin-provoked rat intestinal inflammation by selective inhibition of the inducible nitric oxide synthase. / Szepes, Zoltán; Kiss, József; Lamarque, Dominique; Moran, Anthony P.; Nemcsik, János; Morschl, E.; László, F.; Whittle, Brendan J R.

In: Journal of Physiology Paris, Vol. 95, No. 1-6, 2001, p. 453-455.

Research output: Contribution to journalArticle

Szepes, Zoltán ; Kiss, József ; Lamarque, Dominique ; Moran, Anthony P. ; Nemcsik, János ; Morschl, E. ; László, F. ; Whittle, Brendan J R. / Attenuation of Helicobacter pylori endotoxin-provoked rat intestinal inflammation by selective inhibition of the inducible nitric oxide synthase. In: Journal of Physiology Paris. 2001 ; Vol. 95, No. 1-6. pp. 453-455.
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