Attenuation of Helicobacter pylori endotoxin-provoked rat intestinal inflammation by selective inhibition of the inducible nitric oxide synthase

Zoltán Szepes, József Kiss, Dominique Lamarque, Anthony P. Moran, János Nemcsik, Eva Morschl, Ferenc László, Brendan J.R. Whittle

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We studied the actions of purified Helicobacter pylori endotoxin (3 mg kg-1, i.v.) on rat intestinal vascular permeability (assessed by the radiolabelled human serum albumin leakage technique) and on nitric oxide synthase induction (assessed by the citrulline assay) 4 h later. We found increased albumin leakage and expression of the inducible nitric oxide synthase in jejunum and colon, effects reversed by a selective inducible nitric oxide synthase inhibitor N-(8-(aminomethyl)benzyl)-acetamidine (1400W; 0.2-1 mg kg-1, s.c., concurrently with endotoxin). Thus, H. pylori endotoxin seems to be capable of provoking an inflammatory response in the rat intestinal tissue. Systemic liberation of H. pylori endotoxin might possibly attenuate jejunal and colonic mucosal barrier function, a process mediated by the expression of the inducible nitric oxide synthase.

Original languageEnglish
Pages (from-to)453-455
Number of pages3
JournalJournal of Physiology Paris
Issue number1-6
Publication statusPublished - Nov 12 2001



  • Helicobacter pylori endotoxin
  • Inducible nitric oxide synthase
  • Intestinal inflammation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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