Attention-deficit hyperactivity disorder and suicidality in a treatment naïve sample of children and adolescents

Judit Balazs, Mónika Miklósi, Ágnes Keresztény, Gyöngyvér Dallos, J. Gádoros

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background The aim of the present study was to investigate the possible association between attention-deficit/hyperactivity disorder (ADHD) and suicidality. Methods Using a structured interview (Mini International Neuropsychiatric Interview Kid), the authors examined 418 treatment naïve children/adolescents (aged: 3-18 years). Suicidality was defined by the M.I.N.I. Kid as having any current suicidal ideations and/or suicide attempts. Results Two hundred and eleven children/adolescents fulfilled the DSM-IV diagnosis of ADHD and a further 105 showed symptoms of ADHD in subthreshold level. Multiple mediation analyses resulted in a moderated meditational model in which the relationship between symptoms of ADHD and current suicidality was fully mediated by the symptoms of comorbid conditions, but this was moderated by age. In children under 12 years, significant mediators were the symptoms of specific anxiety disorders, while in the adolescent group symptoms of major depressive episode and dysthymia and symptoms of substance abuse/dependence approved as significant mediators. Limitations As the study was cross-sectional, it did not reveal any causal relationship among the investigated factors. Furthermore, as the study population included a treatment naïve clinical sample, we can assume that adolescents, who and/or whose family seek for help at the first time in this age belonged to the less sever end of the spectrum. Conclusions ADHD symptoms are associated with an increased risk of suicidality in treatment naïve children/adolescents. The mechanisms of this relationship can be understood only when developmental factors are considered. Our findings suggest that clinicians should screen suicidality and comorbid symptoms routinely in patients with ADHD.

Original languageEnglish
Pages (from-to)282-287
Number of pages6
JournalJournal of Affective Disorders
Volume152-154
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Attention Deficit Disorder with Hyperactivity
Substance-Related Disorders
Therapeutics
Interviews
Suicidal Ideation
Anxiety Disorders
Diagnostic and Statistical Manual of Mental Disorders
Suicide
Cross-Sectional Studies
Depression
Population

Keywords

  • ADHD
  • Clinical aspects
  • Comorbidity
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Medicine(all)

Cite this

Attention-deficit hyperactivity disorder and suicidality in a treatment naïve sample of children and adolescents. / Balazs, Judit; Miklósi, Mónika; Keresztény, Ágnes; Dallos, Gyöngyvér; Gádoros, J.

In: Journal of Affective Disorders, Vol. 152-154, No. 1, 01.2014, p. 282-287.

Research output: Contribution to journalArticle

Balazs, Judit ; Miklósi, Mónika ; Keresztény, Ágnes ; Dallos, Gyöngyvér ; Gádoros, J. / Attention-deficit hyperactivity disorder and suicidality in a treatment naïve sample of children and adolescents. In: Journal of Affective Disorders. 2014 ; Vol. 152-154, No. 1. pp. 282-287.
@article{daafb4bce6e8466bb78797e1fcd90fc0,
title = "Attention-deficit hyperactivity disorder and suicidality in a treatment na{\"i}ve sample of children and adolescents",
abstract = "Background The aim of the present study was to investigate the possible association between attention-deficit/hyperactivity disorder (ADHD) and suicidality. Methods Using a structured interview (Mini International Neuropsychiatric Interview Kid), the authors examined 418 treatment na{\"i}ve children/adolescents (aged: 3-18 years). Suicidality was defined by the M.I.N.I. Kid as having any current suicidal ideations and/or suicide attempts. Results Two hundred and eleven children/adolescents fulfilled the DSM-IV diagnosis of ADHD and a further 105 showed symptoms of ADHD in subthreshold level. Multiple mediation analyses resulted in a moderated meditational model in which the relationship between symptoms of ADHD and current suicidality was fully mediated by the symptoms of comorbid conditions, but this was moderated by age. In children under 12 years, significant mediators were the symptoms of specific anxiety disorders, while in the adolescent group symptoms of major depressive episode and dysthymia and symptoms of substance abuse/dependence approved as significant mediators. Limitations As the study was cross-sectional, it did not reveal any causal relationship among the investigated factors. Furthermore, as the study population included a treatment na{\"i}ve clinical sample, we can assume that adolescents, who and/or whose family seek for help at the first time in this age belonged to the less sever end of the spectrum. Conclusions ADHD symptoms are associated with an increased risk of suicidality in treatment na{\"i}ve children/adolescents. The mechanisms of this relationship can be understood only when developmental factors are considered. Our findings suggest that clinicians should screen suicidality and comorbid symptoms routinely in patients with ADHD.",
keywords = "ADHD, Clinical aspects, Comorbidity, Suicide",
author = "Judit Balazs and M{\'o}nika Mikl{\'o}si and {\'A}gnes Kereszt{\'e}ny and Gy{\"o}ngyv{\'e}r Dallos and J. G{\'a}doros",
year = "2014",
month = "1",
doi = "10.1016/j.jad.2013.09.026",
language = "English",
volume = "152-154",
pages = "282--287",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Attention-deficit hyperactivity disorder and suicidality in a treatment naïve sample of children and adolescents

AU - Balazs, Judit

AU - Miklósi, Mónika

AU - Keresztény, Ágnes

AU - Dallos, Gyöngyvér

AU - Gádoros, J.

PY - 2014/1

Y1 - 2014/1

N2 - Background The aim of the present study was to investigate the possible association between attention-deficit/hyperactivity disorder (ADHD) and suicidality. Methods Using a structured interview (Mini International Neuropsychiatric Interview Kid), the authors examined 418 treatment naïve children/adolescents (aged: 3-18 years). Suicidality was defined by the M.I.N.I. Kid as having any current suicidal ideations and/or suicide attempts. Results Two hundred and eleven children/adolescents fulfilled the DSM-IV diagnosis of ADHD and a further 105 showed symptoms of ADHD in subthreshold level. Multiple mediation analyses resulted in a moderated meditational model in which the relationship between symptoms of ADHD and current suicidality was fully mediated by the symptoms of comorbid conditions, but this was moderated by age. In children under 12 years, significant mediators were the symptoms of specific anxiety disorders, while in the adolescent group symptoms of major depressive episode and dysthymia and symptoms of substance abuse/dependence approved as significant mediators. Limitations As the study was cross-sectional, it did not reveal any causal relationship among the investigated factors. Furthermore, as the study population included a treatment naïve clinical sample, we can assume that adolescents, who and/or whose family seek for help at the first time in this age belonged to the less sever end of the spectrum. Conclusions ADHD symptoms are associated with an increased risk of suicidality in treatment naïve children/adolescents. The mechanisms of this relationship can be understood only when developmental factors are considered. Our findings suggest that clinicians should screen suicidality and comorbid symptoms routinely in patients with ADHD.

AB - Background The aim of the present study was to investigate the possible association between attention-deficit/hyperactivity disorder (ADHD) and suicidality. Methods Using a structured interview (Mini International Neuropsychiatric Interview Kid), the authors examined 418 treatment naïve children/adolescents (aged: 3-18 years). Suicidality was defined by the M.I.N.I. Kid as having any current suicidal ideations and/or suicide attempts. Results Two hundred and eleven children/adolescents fulfilled the DSM-IV diagnosis of ADHD and a further 105 showed symptoms of ADHD in subthreshold level. Multiple mediation analyses resulted in a moderated meditational model in which the relationship between symptoms of ADHD and current suicidality was fully mediated by the symptoms of comorbid conditions, but this was moderated by age. In children under 12 years, significant mediators were the symptoms of specific anxiety disorders, while in the adolescent group symptoms of major depressive episode and dysthymia and symptoms of substance abuse/dependence approved as significant mediators. Limitations As the study was cross-sectional, it did not reveal any causal relationship among the investigated factors. Furthermore, as the study population included a treatment naïve clinical sample, we can assume that adolescents, who and/or whose family seek for help at the first time in this age belonged to the less sever end of the spectrum. Conclusions ADHD symptoms are associated with an increased risk of suicidality in treatment naïve children/adolescents. The mechanisms of this relationship can be understood only when developmental factors are considered. Our findings suggest that clinicians should screen suicidality and comorbid symptoms routinely in patients with ADHD.

KW - ADHD

KW - Clinical aspects

KW - Comorbidity

KW - Suicide

UR - http://www.scopus.com/inward/record.url?scp=84889091589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889091589&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2013.09.026

DO - 10.1016/j.jad.2013.09.026

M3 - Article

C2 - 24183487

AN - SCOPUS:84889091589

VL - 152-154

SP - 282

EP - 287

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1

ER -