Figyelemhiányos hiperaktivitásban szenvedo beteg vizsgálata array komparatív genomhibridizációs módszerrel

Translated title of the contribution: Attention deficit hyperactivity disorder analyzed with array comparative genome hybridization method. Case report

Balázs Duga, Márta Czakó, K. Komlósi, Kinga Hadzsiev, Katalin Sümegi, P. Kisfali, Mártonv Melegh, B. Melegh

Research output: Contribution to journalArticle

Abstract

One of the most common psychiatric disorders during childhood is attention deficit hyperactivity disorder, which affects 5-6% of children worldwide. Symptoms include attention deficit, hyperactivity, forgetfulness and weak impulse control. The exact mechanism behind the development of the disease is unknown. However, current data suggest that a strong genetic background is responsible, which explains the frequent occurrence within a family. Literature data show that copy number variations are very common in patients with attention deficit hyperactivity disorder. The authors present a patient with attention deficit hyperactivity disorder who proved to have two approximately 400 kb heterozygous microduplications at 6p25.2 and 15q13.3 chromosomal regions detected by comparative genomic hybridization methods. Both duplications affect genes (6p25.2: SLC22A23; 15q13.3: CHRNA7) which may play a role in the development of attention deficit hyperactivity disorder. This case serves as an example of the wide spectrum of indication of the array comparative genome hybridization method. Orv. Hetil., 2014, 155(40), 1598-1601.

Original languageHungarian
Pages (from-to)1598-1601
Number of pages4
JournalOrvosi Hetilap
Volume155
Issue number40
DOIs
Publication statusPublished - Oct 1 2014

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Comparative Genomic Hybridization
Attention Deficit Disorder with Hyperactivity
Gene Duplication
Psychiatry

ASJC Scopus subject areas

  • Medicine(all)

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Figyelemhiányos hiperaktivitásban szenvedo beteg vizsgálata array komparatív genomhibridizációs módszerrel. / Duga, Balázs; Czakó, Márta; Komlósi, K.; Hadzsiev, Kinga; Sümegi, Katalin; Kisfali, P.; Melegh, Mártonv; Melegh, B.

In: Orvosi Hetilap, Vol. 155, No. 40, 01.10.2014, p. 1598-1601.

Research output: Contribution to journalArticle

Duga, Balázs ; Czakó, Márta ; Komlósi, K. ; Hadzsiev, Kinga ; Sümegi, Katalin ; Kisfali, P. ; Melegh, Mártonv ; Melegh, B. / Figyelemhiányos hiperaktivitásban szenvedo beteg vizsgálata array komparatív genomhibridizációs módszerrel. In: Orvosi Hetilap. 2014 ; Vol. 155, No. 40. pp. 1598-1601.
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