Attempted tumour therapy complicated by a viroid associate of the tumour

K. Lapis, A. J.S. Davies

Research output: Contribution to journalArticle

Abstract

An account is presented of unsuccessful attempts to cure the NK/Ly ascites tumour in mice by doses of Degranol or irradiation which, had they not been followed by syngeneic marrow therapy, would have proved lethal as a consequence of haematopoietic failure. Reasons for the lack of success are discussed and it is concluded firstly that even the high doses of anti-tumour agents given were inisufficient to eradicate the tumour and, secondly, that the treated animals died before the controls because a virus or virus-like entity associated with the tumour seriously impeded haematopoietic recovery.

Original languageEnglish
Pages (from-to)763-769
Number of pages7
JournalBritish journal of cancer
Volume16
Issue number4
DOIs
Publication statusPublished - Dec 1962

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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