Attachment and spreading of human embryonal carcinoma stem cells on nanosurfaces monitored by optical waveguides

A. Aref, R. Horvath, F. Ansari, J. J. Ramsden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cell adhesion is an active process, carried out in vivo via receptor ligand-like interactions between cell surface adhesion molecules and the extracellular matrix. Initial cell surface reactions following contact may trigger multiple responses, which in tum result in either spreading or detachment of the cell. The set of adhesion and attachment molecules mediating the adhesive behaviour of stem cells and the kinetics of their interactions are as yet largely unknown. In this paper we have investigated the attachment and spreading kinetics of human embryonal carcinoma stem cells (TERA2.sp12) onto the planar Si(Ti)O2 waveguides, and covered with poly-L-lysine (PLL) or mucin, acting as substrata for the cells.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages573-576
Number of pages4
Publication statusPublished - Oct 1 2008
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: Jun 1 2008Jun 5 2008

Publication series

NameTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume2

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period6/1/086/5/08

Keywords

  • Attachment
  • Kinetics
  • Optical waveguide
  • Spreading
  • Stem cells

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Aref, A., Horvath, R., Ansari, F., & Ramsden, J. J. (2008). Attachment and spreading of human embryonal carcinoma stem cells on nanosurfaces monitored by optical waveguides. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (pp. 573-576). (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).