Atrial natriuretic peptide modulates N-methyl-D-aspartate-induced hyperexcitability in ethanol-dependent mice

Research output: Contribution to journalArticle

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Abstract

The role of central nervous atrial natriuretic peptide was investigated for behavioral hyperexcitability in alcohol-dependent mice. Mice were made tolerant to and dependent on ethanol with an ethanol-liquid diet for 14 days. Five hours after withdrawal from ethanol, withdrawal symptoms were analyzed by scoring handling-induced convulsions. N-methyl-D-aspartate (NMDA) induced behavioral seizures in a dose-dependent manner, an effect which was more intensive during the ethanol withdrawal period than in alcohol-naive animals. Intracerebroventricular (i.c.v.) injections of α-atrial natriuretic peptide (atrial natriuretic peptide) dose-dependently inhibited, whereas injection of an antiserum against atrial natriuretic peptide potentiated, the seizure-inducing effect of NMDA in ethanol-dependent mice. The main conclusion is that central nervous atrial natriuretic peptide plays a modulatory role in behavioral hyperexcitability during alcohol withdrawal. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalEuropean Journal of Pharmacology
Volume401
Issue number3
DOIs
Publication statusPublished - Aug 11 2000

Fingerprint

Atrial Natriuretic Factor
N-Methylaspartate
Ethanol
Seizures
Alcohols
Substance Withdrawal Syndrome
Injections
Immune Sera
Diet

Keywords

  • ANP (atrial natriuretic peptide)
  • Antiserum against atrial natriuretic peptide
  • Ethanol dependence
  • Ethanol tolerance
  • NMDA (N-methyl-D-aspartate)
  • Withdrawal

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Atrial natriuretic peptide modulates N-methyl-D-aspartate-induced hyperexcitability in ethanol-dependent mice. / Kovács, G.

In: European Journal of Pharmacology, Vol. 401, No. 3, 11.08.2000, p. 343-347.

Research output: Contribution to journalArticle

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