Atrial natriuretic peptide in volume expansion-induced natriuresis in man

T. Tulassay, H. Ruskoaho, M. Tòth, W. Rascher

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The role of atrial natriuretic peptide (ANP) in the extracellular volume expansion (ECVE) induced natriuresis was examined in normal man under basal conditions and following dopamine blockade. Hypotonic ECVE was induced by drinking of 20 ml/kg tap water and subsequent intravenous infusion of 2 1 0,9% saline over a period of 4 hours. This maneuver caused an increase in the plasma concentrations of ANP from 25.8 ± 3.4 (x + SEM) to 59.7 ± 6.7 fmol/ml. There was a dissociation between ANP response and urinary sodium excretion. A transient rise in glomerular filtration rate (GFR), plasma dopamine and a continuous decrease in plasma renin activity, aldosterone, vasopressin, and noradrenaline were observed. The natriuretic response to ECVE was blunted during dopamine blockade by metoclopramide, but plasma ANP, renin activity, catecholamine and vasopressin levels were not affected. However, plasma aldosterone rose. Our data are compatible with the concept that intrarenal dopamine and raised plasma concentration of ANP contribute to the natriuretic response to ECVE, but these hormonal changes do not completely explain the underlying mechanisms.

Original languageEnglish
Pages (from-to)363-380
Number of pages18
JournalClinical and Experimental Hypertension
VolumeA10
Issue number3
DOIs
Publication statusPublished - 1988

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Natriuresis
Atrial Natriuretic Factor
Dopamine
Aldosterone
Vasopressins
Renin
Metoclopramide
Glomerular Filtration Rate
Intravenous Infusions
Drinking
Catecholamines
Norepinephrine
Sodium
Water

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Atrial natriuretic peptide in volume expansion-induced natriuresis in man. / Tulassay, T.; Ruskoaho, H.; Tòth, M.; Rascher, W.

In: Clinical and Experimental Hypertension, Vol. A10, No. 3, 1988, p. 363-380.

Research output: Contribution to journalArticle

Tulassay, T. ; Ruskoaho, H. ; Tòth, M. ; Rascher, W. / Atrial natriuretic peptide in volume expansion-induced natriuresis in man. In: Clinical and Experimental Hypertension. 1988 ; Vol. A10, No. 3. pp. 363-380.
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