Atrial natriuretic peptide (ANF)-containing ceils in the paraventricular nucleus are the major, if not the onlysource of ANF-containing nerve fibers and terminals in the median eminence. One week after bilateral lesioning of the paraventricular nucleus, immunoreactive ANF disappeared almost completely (87-92%) from the median eminence. Theparaventricuio-median eminence ANF system appears to be distinct from the periventricular ANF system. Since adrenal ectomy did not influence median eminence ANF levels in either sham-operated or paraventricular nucleus-lesioned animals, but depleted ANF levels in the preoptic and hypothalamic periventricular nuclei, it would appear that the lattersystem is intimately involved in the CNS control of fluid and electrolyte homeostasis.
- Atrial natriuretic peptide
- Median eminence
- Paraventricular nucleus
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience