Atrial natriuretic peptide in the median eminence is of paraventricular nucleus origin

Miklós Palkovits, Robert L. Eskay, Ferenc A. Antoni

Research output: Contribution to journalArticle

36 Citations (Scopus)


Atrial natriuretic peptide (ANF)-containing ceils in the paraventricular nucleus are the major, if not the onlysource of ANF-containing nerve fibers and terminals in the median eminence. One week after bilateral lesioning of the paraventricular nucleus, immunoreactive ANF disappeared almost completely (87-92%) from the median eminence. Theparaventricuio-median eminence ANF system appears to be distinct from the periventricular ANF system. Since adrenal ectomy did not influence median eminence ANF levels in either sham-operated or paraventricular nucleus-lesioned animals, but depleted ANF levels in the preoptic and hypothalamic periventricular nuclei, it would appear that the lattersystem is intimately involved in the CNS control of fluid and electrolyte homeostasis.

Original languageEnglish
Pages (from-to)542-544
Number of pages3
Issue number6
Publication statusPublished - 1987
Externally publishedYes


  • Adrenalectomy
  • Atrial natriuretic peptide
  • Median eminence
  • Paraventricular nucleus
  • Radioimmunoassay

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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