Atrial natriuretic peptide in the locus coeruleus and its possible role in the regulation of arterial blood pressure, fluid and electrolyte homeostasis

Helmut Geiger, Udo Bahner, M. Palkóvits, August Heidland, R. Bernd Sterzel

Research output: Contribution to journalArticle

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Abstract

Atrial natriuretic fator (ANP) is present in neuronal cells of the locus coeruleus and its vicinity in the pontine tegmentum and moderate amount of ANP is detectable in this area by radioimmunoassay. The ANP (both peripheral and brain-born) is known as a neuropeptide which may influence the body salt and water homeostasis and blood pressure by targeting both central and peripheral regulatory mechanisms. Whether this pontine ANP cell group is involved in any of these regulatory mechanisms, the effect of various types of hypertension and experimental alterations in the salt and water balance on ANP levels was measured by radioimmunoassay in the locus coeruleus of rats. Adrenalectomy, as well as aldosterone and dexamethasone treatments failed to alter ANP levels in the locus coeruleus. Reduced ANP levels were measured in spontaneously hypertensive (both young and adult) rats, and in diabetes insipidus (Brattleboro) rats with vasopressin replacement. In contrast to these situations, elevated ANP levels were found in rats with DOCA-salt or 1-Kidney-1-clip hypertension. These data suggest a link between ANP levels in the locus coeruleus and fluid volume homeostasis. Whether this link is causal and connected with the major activity of locus coeruleus neurons (noradrenergic influence on brain regulatory activities) needs further informations.

Original languageEnglish
Pages (from-to)869-879
Number of pages11
JournalLife Sciences
Volume49
Issue number12
DOIs
Publication statusPublished - 1991

Fingerprint

Locus Coeruleus
Blood pressure
Atrial Natriuretic Factor
Electrolytes
Arterial Pressure
Homeostasis
Fluids
Rats
Salts
Radioimmunoassay
Brain
Brattleboro Rats
Desoxycorticosterone Acetate
Hypertension
Adrenergic Neurons
Diabetes Insipidus
Water
Body Water
Adrenalectomy
Medical problems

ASJC Scopus subject areas

  • Pharmacology

Cite this

Atrial natriuretic peptide in the locus coeruleus and its possible role in the regulation of arterial blood pressure, fluid and electrolyte homeostasis. / Geiger, Helmut; Bahner, Udo; Palkóvits, M.; Heidland, August; Sterzel, R. Bernd.

In: Life Sciences, Vol. 49, No. 12, 1991, p. 869-879.

Research output: Contribution to journalArticle

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