Atrial natriuretic peptide in brain preoptic areas: Implications for fluid and salt homeostasis

H. Geiger, U. Bahner, M. Palkóvits, C. Hugo, E. Niklas, A. Heidland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The influence of adrenalectomy and minteralocorticoid and glucocorticoid treatment on atrial natriuretic peptide (ANP) concentration of 18 microdissected rat brain nuclei was investigated. Adrenalectomy increased ANP levels highly in those brain areas that control water intake (the subfornical organ and supraoptic nucleus) and in the drinking center (the perifornical nucleus and the lateral hypothalamus). In all of these brain regions, aldosterone elevated ANP levels in intact animals. Adrenalectomy decreased ANP levels markedly in the OVLT and preoptic periventricular nucleus, which constitute the so-called AV3V region. The ANP level of these two brain areas was nearly restored to baseline levels both after administration of sodium chloride and after replacement of aldosterone, whereas dexamethasone treatment failed to have any affect.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume13
Issue numberSUPPL. 6
Publication statusPublished - 1989

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Preoptic Area
Atrial Natriuretic Factor
Homeostasis
Salts
Adrenalectomy
Brain
Aldosterone
Drinking
Subfornical Organ
Lateral Hypothalamic Area
Supraoptic Nucleus
Sodium Chloride
Dexamethasone
Glucocorticoids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Atrial natriuretic peptide in brain preoptic areas : Implications for fluid and salt homeostasis. / Geiger, H.; Bahner, U.; Palkóvits, M.; Hugo, C.; Niklas, E.; Heidland, A.

In: Journal of Cardiovascular Pharmacology, Vol. 13, No. SUPPL. 6, 1989.

Research output: Contribution to journalArticle

Geiger, H. ; Bahner, U. ; Palkóvits, M. ; Hugo, C. ; Niklas, E. ; Heidland, A. / Atrial natriuretic peptide in brain preoptic areas : Implications for fluid and salt homeostasis. In: Journal of Cardiovascular Pharmacology. 1989 ; Vol. 13, No. SUPPL. 6.
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