Atrial natriuretic peptide and volume changes in children

T. Tulassay, W. Rascher, D. Ganten, K. Schärer, R. E. Lang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of volume changes on the plasma concentration of atrial natriuretic peptide (ANP) was investigated. In children with chronic renal failure predialysis plasma ANP was higher as compared to normal children and decreased significantly during hemodialysis. The decrease in plasma ANP correlated with body weight reduction. On the other hand, increase in plasma volume by infusion of albumin in children with nephrotic syndrome caused significant rise in plasma ANP and an increased natriuresis. Our data demonstrate that an expanded extracellular fluid volume and/or plasma volume appears to be a major stimulus for the release in ANP in children.

Original languageEnglish
Pages (from-to)695-701
Number of pages7
JournalClinical and Experimental Hypertension
Volume8
Issue number4-5
DOIs
Publication statusPublished - Jan 1 1986

Keywords

  • Albumin infusion
  • Atrial natriuretic fluid
  • Extracellular lfuid
  • Plasma volume

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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