Atrial natriuretic peptide and other vasoactive hormones in nephrotic syndrome

T. Tulassay, W. Rascher, R. E. Lang, H. W. Seyberth, K. Schärer

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Plasma levels of atrial natriuretic peptide (ANP), arginine vasopressin (AVP), renin activity (PRA), aldosterone (PA), catecholamines and urinary prostaglandins (PG), as well as renal function were measured in children in the edematous state of the nephrotic syndrome before and after infusion of human serum albumin. Before albumin infusion, plasma levels of AVP, PRA, PA and noradrenaline (NA) and urinary excretion of PGE2, PGE-Met, PGF(2α) were elevated. The mean value of plasma ANP was in the normal range. Albumin infusion produced a 36% increase in the calculated plasma volume. It was associated with a fivefold rise in the plasma level of ANP (31.6 ± 22.6 vs. 151.4 ± 52 fmol/ml mean, SD), and an significant fall in the levels of PRA, AVP, PA, and NA. Similarly, urinary concentration of PGE2, PGE-Met and PGF(2α) fell. Urine flow, GFR, U(Na)V, FE(Na), and C(Osm) increased significantly, while C(H2O) remained unchanged. The diuresis, natriuresis and GFR correlated with the level of plasma ANP, while urinary sodium excretion did not correlated with PA or NA levels. These findings suggest that ANP plays an important role in albumin induced natriuresis in children with nephrotic syndrome.

Original languageEnglish
Pages (from-to)1391-1395
Number of pages5
JournalKidney International
Volume31
Issue number6
Publication statusPublished - 1987

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Nephrotic Syndrome
Atrial Natriuretic Factor
Aldosterone
Hormones
Arginine Vasopressin
Renin
Norepinephrine
Natriuresis
Prostaglandins F
Prostaglandins E
Dinoprostone
Serum Albumin
Albumins
Plasma Volume
Diuresis
Prostaglandins
Catecholamines
Reference Values
Sodium
Urine

ASJC Scopus subject areas

  • Nephrology

Cite this

Tulassay, T., Rascher, W., Lang, R. E., Seyberth, H. W., & Schärer, K. (1987). Atrial natriuretic peptide and other vasoactive hormones in nephrotic syndrome. Kidney International, 31(6), 1391-1395.

Atrial natriuretic peptide and other vasoactive hormones in nephrotic syndrome. / Tulassay, T.; Rascher, W.; Lang, R. E.; Seyberth, H. W.; Schärer, K.

In: Kidney International, Vol. 31, No. 6, 1987, p. 1391-1395.

Research output: Contribution to journalArticle

Tulassay, T, Rascher, W, Lang, RE, Seyberth, HW & Schärer, K 1987, 'Atrial natriuretic peptide and other vasoactive hormones in nephrotic syndrome', Kidney International, vol. 31, no. 6, pp. 1391-1395.
Tulassay T, Rascher W, Lang RE, Seyberth HW, Schärer K. Atrial natriuretic peptide and other vasoactive hormones in nephrotic syndrome. Kidney International. 1987;31(6):1391-1395.
Tulassay, T. ; Rascher, W. ; Lang, R. E. ; Seyberth, H. W. ; Schärer, K. / Atrial natriuretic peptide and other vasoactive hormones in nephrotic syndrome. In: Kidney International. 1987 ; Vol. 31, No. 6. pp. 1391-1395.
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