Atrial Natriuretic Factor Inhibits the Sympathetic Nervous Activity in One-Kidney, One-Clip Hypertension in the Rat

Waldemar Debinski, Otto Kuchel, Raul Garcia, Nguyen T. Buu, Karoly Racz, Marc Cantin, Jacques Genest

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The one-kidney, one-clip model of rat hypertension was found to have an increased natriuresis following chronic infusion of atrial natriuretic factor (ANF). We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabo-lite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio. These data are compatible with the hypothesis that ANF suppresses the increased sympathetic activity in this model of hypertension and this action combined with opposite changes of dopamine may contribute to the natriuretic effect of ANF.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
Publication statusPublished - Jan 1986


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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