Atrial natriuretic factor inhibits the early pathway of steroid biosynthesis in bovine adrenal cortex

K. Racz, O. Kuchel, M. Cantin, A. De Léan

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We have previously determined that atrial natriuretic factor (ANF) is a potent inhibitor of steroid secretion in cultured bovine zona glomerulosa and fasciculata cells. The present report describes a comparison of the effect produced by ANF on aldosterone, deoxycorticosterone and progesterone secretions by zona glomerulosa cells and on cortisol, corticosterone and progesterone secretions by zona fasciculata cells. The equipotent inhibitory action of ANF on the stimulated secretion of these steroids in both cell types indicates a common site of action prior to progesterone synthesis at which ANF inhibits the steroidogenic pathway.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalFEBS letters
Volume192
Issue number1
DOIs
Publication statusPublished - Nov 11 1985

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Keywords

  • Adrenal steroid secretion
  • Atrial natriuretic factor
  • Zona fasciculata cell
  • Zona glomerulosa cell

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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