Atrial natriuretic factor in spontaneously hypertensive rats

Jolanta Gutkowska, Karel Horky, Christian Lachance, K. Rácz, Raul Garcia, Gaetan Thibault, Otto Kuchel, Jacques Genest, Marc Cantin

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Abstract

The levels of immunoreactive atrial natriuretic factor were evaluated by radioimmunoassay in the atria and plasma of spontaneously hypertensive rats (SHR) and their normotensive control Wistar-Kyoto rats (WKY). The immunoreactive atrial natriuretic factor content in SHR was decreased in comparison with the immunoreactive atrial natriuretic factor content in WKY during the development of hypertension. When compared with WKY of the same age, at age 4 weeks SHR had twice as much immunoreactive atrial natriuretic factor and 1.6 times more at age 8 weeks, but at age 12 weeks both concentrations became similar. Although no difference in plasma content of immunoreactive atrial natriuretic factor was found in 8-week-old animals, at the age of 12 weeks, when the blood pressure started to increase, a higher plasmatic level of immunoreactive atrial natriuretic factor was observed in SHR than in WKY (190 ± 36 pg/ml vs 127 ± 14 pg/ml). At age 16 weeks, both blood pressure and plasma immunoreactive atrial natriuretic factor were higher in SHR (414 ±117 pg/ml) than in WKY (194 ± 28 pg/ml; p <0.01). Separate determinations of immunoreactive atrial natriuretic factor in the right and in the left atrium in 16-and 20-week-old SHR and their WKY controls have shown a lower level of immunoreactive atrial natriuretic factor in the left atrium of 16-week-old male SHR (1.42 ± 0.1 /ig/atrium) than in WKY controls (2.28 ± 0.18 μg/atrium; p <0.01). Similar findings were observed in 20-week-old female SHR in which the level of immunoreactive atrial natriuretic factor in the left atrium (0.96 ± 0.14 μg/atrium) was found to be lower (p <0.02) than that in WKY (1.56 ± 0.31 μg/atrium). The depletion of atrial natriuretic factor in the left atrium may be attributed to an increase of pressure in the left atrium of SHR, leading to stretch of left atrial myoendocrine cells with consequent hypersecretion of immunoreactive atrial natriuretic factor.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalHypertension
Volume8
Issue number4
Publication statusPublished - 1986

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Atrial Natriuretic Factor
Inbred SHR Rats
Inbred WKY Rats
Heart Atria
Blood Pressure
Radioimmunoassay
Hypertension
Pressure

Keywords

  • Atrial natriuretic factor
  • Experimental hypertension
  • Spontaneously hypertensive rats

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Gutkowska, J., Horky, K., Lachance, C., Rácz, K., Garcia, R., Thibault, G., ... Cantin, M. (1986). Atrial natriuretic factor in spontaneously hypertensive rats. Hypertension, 8(4), 137-140.

Atrial natriuretic factor in spontaneously hypertensive rats. / Gutkowska, Jolanta; Horky, Karel; Lachance, Christian; Rácz, K.; Garcia, Raul; Thibault, Gaetan; Kuchel, Otto; Genest, Jacques; Cantin, Marc.

In: Hypertension, Vol. 8, No. 4, 1986, p. 137-140.

Research output: Contribution to journalArticle

Gutkowska, J, Horky, K, Lachance, C, Rácz, K, Garcia, R, Thibault, G, Kuchel, O, Genest, J & Cantin, M 1986, 'Atrial natriuretic factor in spontaneously hypertensive rats', Hypertension, vol. 8, no. 4, pp. 137-140.
Gutkowska J, Horky K, Lachance C, Rácz K, Garcia R, Thibault G et al. Atrial natriuretic factor in spontaneously hypertensive rats. Hypertension. 1986;8(4):137-140.
Gutkowska, Jolanta ; Horky, Karel ; Lachance, Christian ; Rácz, K. ; Garcia, Raul ; Thibault, Gaetan ; Kuchel, Otto ; Genest, Jacques ; Cantin, Marc. / Atrial natriuretic factor in spontaneously hypertensive rats. In: Hypertension. 1986 ; Vol. 8, No. 4. pp. 137-140.
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