Atrial natriuretic factor in specific brain areas of spontaneously hypertensive rats

U. Bahner, H. Geiger, M. Palkóvits, A. Heidland

Research output: Contribution to journalArticle

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Abstract

Atrial natriuretic peptides (atrial natriuretic factor, ANF) are present in a great number of brain areas inside and outside of the blood-brain barrier. The pattern of distribution implies the involvement of ANF in different physiological functions, such as blood pressure regulation, electrolyte and fluid homeostasis, and modulation of the neuroendocrine system. To further investigate a possible involvement of central ANF in spontaneous hypertension, we measured levels of ANF in 18 selected, microdissected brain areas of prehypertensive (4-week-old) and hypertensive (12-week-old) spontaneously hypertensive rats (SHR) and their normotensive control, Wistar-Kyoto rats (WKY), by radioimmunoassay. ANF was significantly decreased in seven brain areas in SHR at both ages investigated; the most pronounced decreases were found in the subfornical organ, in the perifornical and periventricular hypothalamic nuclei, and in the medial preoptic nucleus. In addition, in young SHR ANF was significantly decreased in the organum vasculosum laminae terminalis and increased in the median eminence. After the development of hypertension, a significant decrease of ANF could be detected in four more brain areas (bed nucleus of the stria terminalis, paraventricular and arcuate nuclei, dorsal raphe nucleus) of SHR, as compared with normotensive controls, and the increase in the median eminence was no longer detectable. These results suggest a role for ANF in genetic hypertension and the specific importance of certain brain regions.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalHypertension
Volume12
Issue number5
Publication statusPublished - 1988

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Atrial Natriuretic Factor
Inbred SHR Rats
Brain
Median Eminence
Hypertension
Subfornical Organ
Septal Nuclei
Arcuate Nucleus of Hypothalamus
Neurosecretory Systems
Preoptic Area
Inbred WKY Rats
Paraventricular Hypothalamic Nucleus
Blood-Brain Barrier
Electrolytes
Radioimmunoassay
Homeostasis
Blood Pressure

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Atrial natriuretic factor in specific brain areas of spontaneously hypertensive rats. / Bahner, U.; Geiger, H.; Palkóvits, M.; Heidland, A.

In: Hypertension, Vol. 12, No. 5, 1988, p. 519-524.

Research output: Contribution to journalArticle

Bahner, U, Geiger, H, Palkóvits, M & Heidland, A 1988, 'Atrial natriuretic factor in specific brain areas of spontaneously hypertensive rats', Hypertension, vol. 12, no. 5, pp. 519-524.
Bahner, U. ; Geiger, H. ; Palkóvits, M. ; Heidland, A. / Atrial natriuretic factor in specific brain areas of spontaneously hypertensive rats. In: Hypertension. 1988 ; Vol. 12, No. 5. pp. 519-524.
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