ATP production optimization in biochemical mass action models with protein turnover

Dávid Csercsik, G. Szederkényi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We introduce a simple approach to account for the ATP consumption and production in the case of mass action models of metabolic pathways including protein turnover. Under some simplifying assumptions, the method makes it possible to characterize the optimal rate of enzyme synthesis if the substrate concentrations and other rate constants are known. Furthermore we demonstrate that the proposed approach is capable of the comparison of the efficiency of different feedback laws in dynamic environment, considering time-varying substrate concentration.

Original languageEnglish
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
Pages42-47
Number of pages6
Volume1
EditionPART 1
DOIs
Publication statusPublished - 2013
Event1st IFAC Workshop on Thermodynamic Foundations of Mathematical Systems Theory, TFMST 2013 - Lyon, France
Duration: Jul 13 2013Jul 16 2013

Other

Other1st IFAC Workshop on Thermodynamic Foundations of Mathematical Systems Theory, TFMST 2013
CountryFrance
CityLyon
Period7/13/137/16/13

Fingerprint

Adenosinetriphosphate
Proteins
Substrates
Rate constants
Enzymes
Feedback
Metabolic Networks and Pathways

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Csercsik, D., & Szederkényi, G. (2013). ATP production optimization in biochemical mass action models with protein turnover. In IFAC Proceedings Volumes (IFAC-PapersOnline) (PART 1 ed., Vol. 1, pp. 42-47) https://doi.org/10.3182/20130714-3-FR-4040.00017

ATP production optimization in biochemical mass action models with protein turnover. / Csercsik, Dávid; Szederkényi, G.

IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 1 PART 1. ed. 2013. p. 42-47.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Csercsik, D & Szederkényi, G 2013, ATP production optimization in biochemical mass action models with protein turnover. in IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 edn, vol. 1, pp. 42-47, 1st IFAC Workshop on Thermodynamic Foundations of Mathematical Systems Theory, TFMST 2013, Lyon, France, 7/13/13. https://doi.org/10.3182/20130714-3-FR-4040.00017
Csercsik, Dávid ; Szederkényi, G. / ATP production optimization in biochemical mass action models with protein turnover. IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 1 PART 1. ed. 2013. pp. 42-47
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