ATP-citrate lyase and other enzymes of acetyl-CoA metabolism in fractions of small and large synaptosomes from rat brain hippocampus and cerebellum

A. Szutowicz, N. F. Harris, P. Srere, I. L. Crawford

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The activities of choline acetyltransferase and ATP-citrate lyase were significantly correlated (r = 0.995) in fractions of small and large synaptosomes isolated from rat hippocampus and cerebellum. The activities of these two enzymes did not correlate with those of pyruvate dehydrogenase, carnitine acetyltransferase, citrate synthase, acetyl-CoA synthetase, lactate dehydrogenase, or with the rate of high-affinity glutamate uptake in the synaptosomal fractions. The results provide additional evidence linking ATP-citrate lyase to the cholinergic system in the brain.

Original languageEnglish
Pages (from-to)1502-1505
Number of pages4
JournalJournal of Neurochemistry
Volume41
Issue number5
Publication statusPublished - 1983

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ATP Citrate (pro-S)-Lyase
Acetyl Coenzyme A
Synaptosomes
Metabolism
Cerebellum
Rats
Hippocampus
Brain
Carnitine O-Acetyltransferase
Acetate-CoA Ligase
Citrate (si)-Synthase
Choline O-Acetyltransferase
Enzymes
Pyruvic Acid
L-Lactate Dehydrogenase
Cholinergic Agents
Glutamic Acid
Oxidoreductases

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

ATP-citrate lyase and other enzymes of acetyl-CoA metabolism in fractions of small and large synaptosomes from rat brain hippocampus and cerebellum. / Szutowicz, A.; Harris, N. F.; Srere, P.; Crawford, I. L.

In: Journal of Neurochemistry, Vol. 41, No. 5, 1983, p. 1502-1505.

Research output: Contribution to journalArticle

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