Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells

Agnieszka Loboda, Agnieszka Jazwa, Alicja Jozkowicz, Jerzy Dorosz, Jozsef Balla, Grietje Molema, Jozef Dulak

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Beneficial cardiovascular effects of statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are particularly assigned to the modulation of inflammation. Endothelial nitric oxide synthase (eNOS) and heme oxygenase-1 (HO-1) are listed among the crucial protective, anti-inflammatory genes in the vasculature. Here we show that atorvastatin at pharmacologically relevant concentration (0.1 μM) enhanced the expression of eNOS in human microvascular endothelial cells (HMEC-1). Moreover, atorvastatin prevented hypoxia-induced decrease in eNOS expression. However, in the same cells atorvastatin was ineffective in modulation of HO-1 protein level. Therefore, we suggest that the protective effect of statins at their pharmacological concentrations is not mediated by enhancement of HO-1 activity, but may involve eNOS.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalAtherosclerosis
Volume187
Issue number1
DOIs
Publication statusPublished - Jul 1 2006

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Keywords

  • Angiogenesis
  • Atherosclerosis
  • Hypercholesterolemia
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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