Atmospheric pressure cold plasma synthesis of submicrometer-sized pharmaceuticals with improved physicochemical properties

Norbert Radacsi, Rita Ambrus, P. Szabó-Révész, Antoine Van Der Heijden, Joop H. Ter Horst

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A reduction in particle size is one of the strategies to enhance the dissolution behavior of low water-soluble drugs such as niflumic acid. Atmospheric pressure cold plasma crystallization is a novel technique to achieve such submicrometer particles. This technique uses a surface dielectric barrier discharge (SDBD) plasma that both charges and heats solution droplets. Atmospheric pressure cold plasma crystallization was used to produce niflumic acid crystals and its excipient, Poloxamer 188, with a significant decrease in size compared to the conventional products. A substantial increase in dissolution rate of the submicrometer niflumic acid was observed in the presence of the plasma-made excipient.

Original languageEnglish
Pages (from-to)5090-5095
Number of pages6
JournalCrystal Growth and Design
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 3 2012

Fingerprint

Niflumic Acid
Plasma Gases
cold plasmas
Drug products
Atmospheric pressure
atmospheric pressure
Excipients
Crystallization
Plasmas
acids
dissolving
Dissolution
synthesis
Pharmaceutical Preparations
crystallization
Acids
Poloxamer
plasma jets
drugs
Particle size

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Atmospheric pressure cold plasma synthesis of submicrometer-sized pharmaceuticals with improved physicochemical properties. / Radacsi, Norbert; Ambrus, Rita; Szabó-Révész, P.; Van Der Heijden, Antoine; Ter Horst, Joop H.

In: Crystal Growth and Design, Vol. 12, No. 10, 03.10.2012, p. 5090-5095.

Research output: Contribution to journalArticle

Radacsi, Norbert ; Ambrus, Rita ; Szabó-Révész, P. ; Van Der Heijden, Antoine ; Ter Horst, Joop H. / Atmospheric pressure cold plasma synthesis of submicrometer-sized pharmaceuticals with improved physicochemical properties. In: Crystal Growth and Design. 2012 ; Vol. 12, No. 10. pp. 5090-5095.
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