Atheromatosis extent in coronary artery disease is not correlated with apolipoprotein-E polymorphism and its plasma levels, but associated with cognitive decline

L. M. Lima, M. d G Carvalho, C. N. Ferreira, A. P. Fernandes, C. P d F Neto, J. C F Garcia, H. J. Reis, Z. Janka, A. Palotás, M. d O Sousa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Apolipoprotein-E (apoE) 4 allele is a known risk factor for Alzheimer's disease (AD). Polymorphism of apoE is also one of the most important genetic markers for coronary artery disease (CAD). The allelic variation in the apoE gene has a significant effect on inter-individual variation of lipids and lipoprotein plasma levels as well. This study investigated whether apoE polymorphism affects the plasma levels of apoE and the possible association to CAD extent and cognitive functions. Methods: Plasma apoE levels and apoE genotypes were evaluated of subjects with normal coronary arteries, and individuals with angiographycally confirmed mild/moderate or severe atheromatosis. The cognitive performance of the volunteers was also measured by mini-mental state examination (MMSE). Results: Out of the 6 expected genotypes, only 5 were detected in participants: E3/3 (56.0%), E3/4 (23.6%), E4/4 (8.2%), E2/4 (3.3%), E2/3 (8.9%). The ε3 allele (72%) was the most frequent, followed by ε4 (22%) and ε2 (6%). No difference was found in plasma levels of either apoE or in apoE genotype frequencies among the groups, however MMSE scores of CAD patients irrespective of their atheromatosis extent were significantly lower than that seen in the normal population. Conclusions: Although neither apoE plasma levels, nor apoE polymorphism in patients presenting with mild/moderate or severe atheromatosis showed to be associated with CAD severity, the presence of atheromatosis in the heart vessels positively correlated with cognitive dysfunction.

Original languageEnglish
Pages (from-to)556-563
Number of pages8
JournalCurrent Alzheimer Research
Volume7
Issue number6
DOIs
Publication statusPublished - 2010

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Apolipoproteins E
Coronary Artery Disease
Genotype
Alleles
Cognitive Dysfunction
Apolipoprotein E4
Genetic Markers
Cognition
Lipoproteins
Volunteers
Coronary Vessels
Alzheimer Disease
Lipids

Keywords

  • Alzheimer's disease
  • Apolipoprotein-E
  • Atheromatosis
  • Cognitive impairment
  • Coronary artery disease
  • Plasma levels
  • Polymorphism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Atheromatosis extent in coronary artery disease is not correlated with apolipoprotein-E polymorphism and its plasma levels, but associated with cognitive decline. / Lima, L. M.; Carvalho, M. d G; Ferreira, C. N.; Fernandes, A. P.; Neto, C. P d F; Garcia, J. C F; Reis, H. J.; Janka, Z.; Palotás, A.; Sousa, M. d O.

In: Current Alzheimer Research, Vol. 7, No. 6, 2010, p. 556-563.

Research output: Contribution to journalArticle

Lima, L. M. ; Carvalho, M. d G ; Ferreira, C. N. ; Fernandes, A. P. ; Neto, C. P d F ; Garcia, J. C F ; Reis, H. J. ; Janka, Z. ; Palotás, A. ; Sousa, M. d O. / Atheromatosis extent in coronary artery disease is not correlated with apolipoprotein-E polymorphism and its plasma levels, but associated with cognitive decline. In: Current Alzheimer Research. 2010 ; Vol. 7, No. 6. pp. 556-563.
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abstract = "Background: Apolipoprotein-E (apoE) 4 allele is a known risk factor for Alzheimer's disease (AD). Polymorphism of apoE is also one of the most important genetic markers for coronary artery disease (CAD). The allelic variation in the apoE gene has a significant effect on inter-individual variation of lipids and lipoprotein plasma levels as well. This study investigated whether apoE polymorphism affects the plasma levels of apoE and the possible association to CAD extent and cognitive functions. Methods: Plasma apoE levels and apoE genotypes were evaluated of subjects with normal coronary arteries, and individuals with angiographycally confirmed mild/moderate or severe atheromatosis. The cognitive performance of the volunteers was also measured by mini-mental state examination (MMSE). Results: Out of the 6 expected genotypes, only 5 were detected in participants: E3/3 (56.0{\%}), E3/4 (23.6{\%}), E4/4 (8.2{\%}), E2/4 (3.3{\%}), E2/3 (8.9{\%}). The ε3 allele (72{\%}) was the most frequent, followed by ε4 (22{\%}) and ε2 (6{\%}). No difference was found in plasma levels of either apoE or in apoE genotype frequencies among the groups, however MMSE scores of CAD patients irrespective of their atheromatosis extent were significantly lower than that seen in the normal population. Conclusions: Although neither apoE plasma levels, nor apoE polymorphism in patients presenting with mild/moderate or severe atheromatosis showed to be associated with CAD severity, the presence of atheromatosis in the heart vessels positively correlated with cognitive dysfunction.",
keywords = "Alzheimer's disease, Apolipoprotein-E, Atheromatosis, Cognitive impairment, Coronary artery disease, Plasma levels, Polymorphism",
author = "Lima, {L. M.} and Carvalho, {M. d G} and Ferreira, {C. N.} and Fernandes, {A. P.} and Neto, {C. P d F} and Garcia, {J. C F} and Reis, {H. J.} and Z. Janka and A. Palot{\'a}s and Sousa, {M. d O}",
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T1 - Atheromatosis extent in coronary artery disease is not correlated with apolipoprotein-E polymorphism and its plasma levels, but associated with cognitive decline

AU - Lima, L. M.

AU - Carvalho, M. d G

AU - Ferreira, C. N.

AU - Fernandes, A. P.

AU - Neto, C. P d F

AU - Garcia, J. C F

AU - Reis, H. J.

AU - Janka, Z.

AU - Palotás, A.

AU - Sousa, M. d O

PY - 2010

Y1 - 2010

N2 - Background: Apolipoprotein-E (apoE) 4 allele is a known risk factor for Alzheimer's disease (AD). Polymorphism of apoE is also one of the most important genetic markers for coronary artery disease (CAD). The allelic variation in the apoE gene has a significant effect on inter-individual variation of lipids and lipoprotein plasma levels as well. This study investigated whether apoE polymorphism affects the plasma levels of apoE and the possible association to CAD extent and cognitive functions. Methods: Plasma apoE levels and apoE genotypes were evaluated of subjects with normal coronary arteries, and individuals with angiographycally confirmed mild/moderate or severe atheromatosis. The cognitive performance of the volunteers was also measured by mini-mental state examination (MMSE). Results: Out of the 6 expected genotypes, only 5 were detected in participants: E3/3 (56.0%), E3/4 (23.6%), E4/4 (8.2%), E2/4 (3.3%), E2/3 (8.9%). The ε3 allele (72%) was the most frequent, followed by ε4 (22%) and ε2 (6%). No difference was found in plasma levels of either apoE or in apoE genotype frequencies among the groups, however MMSE scores of CAD patients irrespective of their atheromatosis extent were significantly lower than that seen in the normal population. Conclusions: Although neither apoE plasma levels, nor apoE polymorphism in patients presenting with mild/moderate or severe atheromatosis showed to be associated with CAD severity, the presence of atheromatosis in the heart vessels positively correlated with cognitive dysfunction.

AB - Background: Apolipoprotein-E (apoE) 4 allele is a known risk factor for Alzheimer's disease (AD). Polymorphism of apoE is also one of the most important genetic markers for coronary artery disease (CAD). The allelic variation in the apoE gene has a significant effect on inter-individual variation of lipids and lipoprotein plasma levels as well. This study investigated whether apoE polymorphism affects the plasma levels of apoE and the possible association to CAD extent and cognitive functions. Methods: Plasma apoE levels and apoE genotypes were evaluated of subjects with normal coronary arteries, and individuals with angiographycally confirmed mild/moderate or severe atheromatosis. The cognitive performance of the volunteers was also measured by mini-mental state examination (MMSE). Results: Out of the 6 expected genotypes, only 5 were detected in participants: E3/3 (56.0%), E3/4 (23.6%), E4/4 (8.2%), E2/4 (3.3%), E2/3 (8.9%). The ε3 allele (72%) was the most frequent, followed by ε4 (22%) and ε2 (6%). No difference was found in plasma levels of either apoE or in apoE genotype frequencies among the groups, however MMSE scores of CAD patients irrespective of their atheromatosis extent were significantly lower than that seen in the normal population. Conclusions: Although neither apoE plasma levels, nor apoE polymorphism in patients presenting with mild/moderate or severe atheromatosis showed to be associated with CAD severity, the presence of atheromatosis in the heart vessels positively correlated with cognitive dysfunction.

KW - Alzheimer's disease

KW - Apolipoprotein-E

KW - Atheromatosis

KW - Cognitive impairment

KW - Coronary artery disease

KW - Plasma levels

KW - Polymorphism

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