Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila

G. Juhász, Balázs Érdi, M. Sass, Thomas P. Neufeld

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

Autophagy, a cellular process of cytoplasmic degradation and recycling, is induced in Drosophila larval tissues during metamorphosis, potentially contributing to their destruction or reorganization. Unexpectedly, we find that flies lacking the core autophagy regulator Atg7 are viable, despite severe defects in autophagy. Although metamorphic cell death is perturbed in Atg7 mutants, the larval-adult midgut transition proceeds normally, with extended pupal development compensating for reduced autophagy. Atg7?/? adults are short-lived, hypersensitive to nutrient and oxidative stress, and accumulate ubiquitin-positive aggregates in degenerating neurons. Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis.

Original languageEnglish
Pages (from-to)3061-3066
Number of pages6
JournalGenes and Development
Volume21
Issue number23
DOIs
Publication statusPublished - Dec 1 2007

Fingerprint

Autophagy
Drosophila
Health
Recycling
Ubiquitin
Diptera
Oxidative Stress
Cell Death
Neurons
Food

Keywords

  • Atg7
  • Autophagy
  • Drosophila
  • Longevity
  • Metamorphosis
  • Neurodegeneration

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. / Juhász, G.; Érdi, Balázs; Sass, M.; Neufeld, Thomas P.

In: Genes and Development, Vol. 21, No. 23, 01.12.2007, p. 3061-3066.

Research output: Contribution to journalArticle

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