Asymptotic output tracking in blood glucose control. A case study

Levente Kovacs, Peter Szalay, Balazs Benyo, Geoffrey J. Chase

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Glucose is the primary source of energy for the human body. Keeping the blood glucose level between certain thresholds is essential for the proper energy transport. Insulin plays a key role in maintaining the glucose homeostasis. Because of its great importance, many models were published on either to describe the glucose-insulin interaction in case of patients under Intensive Care Unit (ICU), or to model Type 1 Diabetes Mellitus (T1DM). Currently for most of the models linear control concepts are used in order to design an appropriate controller. The aim of the current paper is to investigate applicability of nonlinear control theory providing exact mathematical background in the control problem of glucose-insulin interaction. Both ICU and T1DM cases are analyzed on well-known models with different complexity. Our aim is to hide the nonlinearity of the models by transforming the input signal so that the response of the model would mimic the behavior of a linear system; hence extending the validity of linear controllers. The asymptotic tracking problem needs the value of the state variables; therefore extended Kalman-filter is applied. The capabilities of this approach are examined through classical control algorithms and input data recorded in clinical environment.

Original languageEnglish
Title of host publication2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011
Pages59-64
Number of pages6
DOIs
Publication statusPublished - Dec 1 2011
Event2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011 - Orlando, FL, United States
Duration: Dec 12 2011Dec 15 2011

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0191-2216

Other

Other2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011
CountryUnited States
CityOrlando, FL
Period12/12/1112/15/11

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Modelling and Simulation
  • Control and Optimization

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  • Cite this

    Kovacs, L., Szalay, P., Benyo, B., & Chase, G. J. (2011). Asymptotic output tracking in blood glucose control. A case study. In 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011 (pp. 59-64). [6161400] (Proceedings of the IEEE Conference on Decision and Control). https://doi.org/10.1109/CDC.2011.6161400