Asztrociták egészségben és betegségben

Translated title of the contribution: Astrocytes in health and disease

Marianna Murányi, Zsombor Lacza

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

It is now known that astrocytes are not merely supporting cells but they also play an important role m neuronal functions. Astrocytes tightly ensheat neuronal synapses and regulate the excitation of neurons by uptaking neurotransmitters; regulate the cerebral blood flow, cerebral fluid volume and extracellular concentrations of ions. They also supply fuel in the form of lactate and provide free radical scavangers such as glutathione for active neurons. These facts indicate that impaired function of astrocytes may lead to neuronal dysfunction. After brain injury (stroke, trauma or tumors) astrocytes are swollen and release active molecules such as glutamate or free radicals resulting in neuronal dysfunction. Thus, investigation of the molecular mechanisms of astrocyte function may reveal novel targets for the development of therapeutic tools in neuronal diseases.

Original languageHungarian
Pages (from-to)697-702
Number of pages6
JournalOrvosi hetilap
Volume148
Issue number15
DOIs
Publication statusPublished - Apr 15 2007

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ASJC Scopus subject areas

  • Medicine(all)

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