Asthma endophenotypes and polymorphisms in the histamine receptor HRH4 gene

Tunde Simon, Agnes F. Semsei, Ildiko Ungvri, Eva Hadadi, Viktor Virag, Adrienne Nagy, Monika S. Vangor, Valeria Laszl, Csaba Szalai, Andrs Falus

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18 Citations (Scopus)

Abstract

Background: Histamine as an inflammatory mediator plays an important role in chronic allergic and asthmatic conditions. However, the role of genetic polymorphisms of the histamine receptor HRH4 (histamine receptor H4) gene in asthma susceptibility and endophenotypes has not been studied yet. Our aim was to investigate the possible association between single nucleotide polymorphisms (SNPs) in the HRH4 gene and asthma or some endophenotypes of asthma. Methods: Twenty-one SNPs of the HRH4 gene were genotyped in 313 asthmatic patients and 360 controls using Sequenom® iPLEX® Gold Genotyping Technology. Results: Genotype distribution of three HRH4 SNPs, namely rs17187619 [p = 0.002; odds ratio, OR (95% confidence interval, CI) = 2.4 (4.1-1.4)], rs527790 [p = 0.0002; OR (95% CI) = 3.3 (6.1-1.8)] and rs487202 [p = 0.00007; OR (95% CI) = 3.5 (6.6-1.9)] differed significantly between patients with or without infection-induced asthma. Haplotypes, which included the rs4800573-rs527790 CC allele combination, were found to be associated w3 ith infection-induced asthma [p = 0.0009, OR (95% CI) = 0.5 (0.4-0.8)]. The rs487202-rs574913 CA haplotype was more frequent among patients with infection-induced asthma [p = 0.0006, OR (95% CI) = 1.9 (1.3-2.6)]. None of the SNPs contributed directly to the risk of asthma. Conclusions: Our results suggest that genetic variation in the HRH4 gene might influence the pathogenesis of infection-induced asthma.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalInternational archives of allergy and immunology
Volume159
Issue number2
DOIs
Publication statusPublished - Sep 1 2012

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Keywords

  • Histamine receptor H4
  • Infection-induced asthma
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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