Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium

Albert Rosenberger, Heike Bickeböller, Valerie McCormack, Darren R. Brenner, Eric J. Duell, Anne Tjønneland, Soren Friis, Joshua E. Muscat, Ping Yang, H. Erich Wichmann, Joachim Heinrich, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, David Zaridze, P. Rudnai, Eleonora Fabianova, Vladimir Janout, Vladimir Bencko, Paul Brennan, Dana MatesAnn G. Schwartz, Michele L. Cote, Zuo Feng Zhang, Hal Morgenstern, Sam S. Oh, John K. Field, Olaide Raji, John R. McLaughlin, John Wiencke, Loic LeMarchand, Monica Neri, Stefano Bonassi, Angeline S. Andrew, Qing Lan, Wei Hu, Irene Orlow, Bernard J. Park, Paolo Boffetta, Rayjean J. Hung

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Abstract

Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I2 = 73%, P <0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 9=%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 9=% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.

Original languageEnglish
Pages (from-to)587-597
Number of pages11
JournalCarcinogenesis
Volume33
Issue number3
DOIs
Publication statusPublished - 2012

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Lung Neoplasms
Asthma
Confidence Intervals
Small Cell Carcinoma
Meta-Analysis
Squamous Cell Carcinoma
Adenocarcinoma
Epithelial Cells
Lung
Incidence

ASJC Scopus subject areas

  • Cancer Research

Cite this

Rosenberger, A., Bickeböller, H., McCormack, V., Brenner, D. R., Duell, E. J., Tjønneland, A., ... Hung, R. J. (2012). Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium. Carcinogenesis, 33(3), 587-597. https://doi.org/10.1093/carcin/bgr307

Asthma and lung cancer risk : A systematic investigation by the international lung cancer consortium. / Rosenberger, Albert; Bickeböller, Heike; McCormack, Valerie; Brenner, Darren R.; Duell, Eric J.; Tjønneland, Anne; Friis, Soren; Muscat, Joshua E.; Yang, Ping; Wichmann, H. Erich; Heinrich, Joachim; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Zaridze, David; Rudnai, P.; Fabianova, Eleonora; Janout, Vladimir; Bencko, Vladimir; Brennan, Paul; Mates, Dana; Schwartz, Ann G.; Cote, Michele L.; Zhang, Zuo Feng; Morgenstern, Hal; Oh, Sam S.; Field, John K.; Raji, Olaide; McLaughlin, John R.; Wiencke, John; LeMarchand, Loic; Neri, Monica; Bonassi, Stefano; Andrew, Angeline S.; Lan, Qing; Hu, Wei; Orlow, Irene; Park, Bernard J.; Boffetta, Paolo; Hung, Rayjean J.

In: Carcinogenesis, Vol. 33, No. 3, 2012, p. 587-597.

Research output: Contribution to journalArticle

Rosenberger, A, Bickeböller, H, McCormack, V, Brenner, DR, Duell, EJ, Tjønneland, A, Friis, S, Muscat, JE, Yang, P, Wichmann, HE, Heinrich, J, Szeszenia-Dabrowska, N, Lissowska, J, Zaridze, D, Rudnai, P, Fabianova, E, Janout, V, Bencko, V, Brennan, P, Mates, D, Schwartz, AG, Cote, ML, Zhang, ZF, Morgenstern, H, Oh, SS, Field, JK, Raji, O, McLaughlin, JR, Wiencke, J, LeMarchand, L, Neri, M, Bonassi, S, Andrew, AS, Lan, Q, Hu, W, Orlow, I, Park, BJ, Boffetta, P & Hung, RJ 2012, 'Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium', Carcinogenesis, vol. 33, no. 3, pp. 587-597. https://doi.org/10.1093/carcin/bgr307
Rosenberger A, Bickeböller H, McCormack V, Brenner DR, Duell EJ, Tjønneland A et al. Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium. Carcinogenesis. 2012;33(3):587-597. https://doi.org/10.1093/carcin/bgr307
Rosenberger, Albert ; Bickeböller, Heike ; McCormack, Valerie ; Brenner, Darren R. ; Duell, Eric J. ; Tjønneland, Anne ; Friis, Soren ; Muscat, Joshua E. ; Yang, Ping ; Wichmann, H. Erich ; Heinrich, Joachim ; Szeszenia-Dabrowska, Neonila ; Lissowska, Jolanta ; Zaridze, David ; Rudnai, P. ; Fabianova, Eleonora ; Janout, Vladimir ; Bencko, Vladimir ; Brennan, Paul ; Mates, Dana ; Schwartz, Ann G. ; Cote, Michele L. ; Zhang, Zuo Feng ; Morgenstern, Hal ; Oh, Sam S. ; Field, John K. ; Raji, Olaide ; McLaughlin, John R. ; Wiencke, John ; LeMarchand, Loic ; Neri, Monica ; Bonassi, Stefano ; Andrew, Angeline S. ; Lan, Qing ; Hu, Wei ; Orlow, Irene ; Park, Bernard J. ; Boffetta, Paolo ; Hung, Rayjean J. / Asthma and lung cancer risk : A systematic investigation by the international lung cancer consortium. In: Carcinogenesis. 2012 ; Vol. 33, No. 3. pp. 587-597.
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abstract = "Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95{\%} confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I2 = 73{\%}, P <0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 9={\%}, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 9={\%} CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95{\%} CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95{\%} CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95{\%} CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.",
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AU - Rosenberger, Albert

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AU - Brenner, Darren R.

AU - Duell, Eric J.

AU - Tjønneland, Anne

AU - Friis, Soren

AU - Muscat, Joshua E.

AU - Yang, Ping

AU - Wichmann, H. Erich

AU - Heinrich, Joachim

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Zaridze, David

AU - Rudnai, P.

AU - Fabianova, Eleonora

AU - Janout, Vladimir

AU - Bencko, Vladimir

AU - Brennan, Paul

AU - Mates, Dana

AU - Schwartz, Ann G.

AU - Cote, Michele L.

AU - Zhang, Zuo Feng

AU - Morgenstern, Hal

AU - Oh, Sam S.

AU - Field, John K.

AU - Raji, Olaide

AU - McLaughlin, John R.

AU - Wiencke, John

AU - LeMarchand, Loic

AU - Neri, Monica

AU - Bonassi, Stefano

AU - Andrew, Angeline S.

AU - Lan, Qing

AU - Hu, Wei

AU - Orlow, Irene

AU - Park, Bernard J.

AU - Boffetta, Paolo

AU - Hung, Rayjean J.

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N2 - Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I2 = 73%, P <0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 9=%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 9=% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.

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