Associations of body mass index and weight loss with mortality in transplant-waitlisted maintenance hemodialysis patients

M. Molnár, E. Streja, C. P. Kovesdy, S. Bunnapradist, M. S. Sampaio, J. Jing, M. Krishnan, A. R. Nissenson, G. M. Danovitch, K. Kalantar-Zadeh

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

A body mass index (BMI) below morbid obesity range is often a requirement for kidney transplant wait-listing, but data linking BMI changes to mortality during the waitlist period are lacking. By linking the 6-year (7/2001-6/2007) national databases of a large dialysis organization and the Scientific Registry of Transplant Recipients, we identified 14 632 waitlisted hemodialysis patients without kidney transplantation. Time-dependent survival models examined the mortality predictability of 13-week-averaged BMI, pretransplant serum creatinine as a muscle mass surrogate and their changes over time. The patients were on average 52 ± 13 years old, 40% women and had a BMI of 26.9 ± 6.3 kg/m2. Each kg/m2 increase of BMI was associated with a death hazard ratio (HR) of 0.96 (95%CI: 0.95-0.97). Compared to the lowest creatinine quintile, the 4th and 5th quintiles had death HRs of 0.75 (0.66-0.86) and 0.57 (0.49-0.66), respectively. Compared to minimal (<± 1 kg) weight change over 6 months, those with 3 kg-

Original languageEnglish
Pages (from-to)725-736
Number of pages12
JournalAmerican Journal of Transplantation
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Renal Dialysis
Weight Loss
Body Mass Index
Maintenance
Transplants
Mortality
Creatinine
Morbid Obesity
Kidney Transplantation
Registries
Dialysis
Organizations
Databases
Kidney
Weights and Measures
Muscles
Survival
Serum

Keywords

  • Dialysis
  • malnutrition-inflammation complex syndrome
  • muscle mass
  • obesity
  • survival
  • transplantation waiting list
  • weight loss

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Associations of body mass index and weight loss with mortality in transplant-waitlisted maintenance hemodialysis patients. / Molnár, M.; Streja, E.; Kovesdy, C. P.; Bunnapradist, S.; Sampaio, M. S.; Jing, J.; Krishnan, M.; Nissenson, A. R.; Danovitch, G. M.; Kalantar-Zadeh, K.

In: American Journal of Transplantation, Vol. 11, No. 4, 04.2011, p. 725-736.

Research output: Contribution to journalArticle

Molnár, M, Streja, E, Kovesdy, CP, Bunnapradist, S, Sampaio, MS, Jing, J, Krishnan, M, Nissenson, AR, Danovitch, GM & Kalantar-Zadeh, K 2011, 'Associations of body mass index and weight loss with mortality in transplant-waitlisted maintenance hemodialysis patients', American Journal of Transplantation, vol. 11, no. 4, pp. 725-736. https://doi.org/10.1111/j.1600-6143.2011.03468.x
Molnár, M. ; Streja, E. ; Kovesdy, C. P. ; Bunnapradist, S. ; Sampaio, M. S. ; Jing, J. ; Krishnan, M. ; Nissenson, A. R. ; Danovitch, G. M. ; Kalantar-Zadeh, K. / Associations of body mass index and weight loss with mortality in transplant-waitlisted maintenance hemodialysis patients. In: American Journal of Transplantation. 2011 ; Vol. 11, No. 4. pp. 725-736.
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