Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study

Idoia Labayen, Luis A. Moreno, Jonatan R. Ruiz, Francisco B. Ortega, Michael Sjostrom, Inge Huybrechts, Marcela Gonzalez-Gross, André Spinneker, Stefaan De Henauw, Yannis Manios, Dénés Molnar, Catherine Leclercq, Frédéric Gottrand

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14 Citations (Scopus)

Abstract

Objectives: Nutritional factors in early life may have long-term physiologic effects in humans. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) play important roles in protecting against cardiovascular disease (CVD) risk. Our aim was to examine the association of birth weight (BW) with serum long chain polyunsaturated fatty acids (LCPUFA) profile in adolescents. Subjects and methods: A total of 772 European adolescents (56.3% females) aged 14.7 ± 1.2 years were included in this study. Information on BW and gestational age was obtained from parental records. DHA, EPA and arachidonic acid (AA) concentrations were measured in serum phospholipids. Alfa-linolenic (ALA), linoleic (LA), AA, EPA and DHA intakes assessed by a computer based 24 h dietary recall. Gender, gestational age, pubertal status, body mass index, center and total energy and LCPUFA intakes were used as confounders in all the analyses. Results: BW was significantly associated with serum DHA and EPA (both adjusted P<. 0.05) independently of potential confounders including their main dietetic source. We did not observe any significant relationship between BW and serum AA levels. Conclusions: Our findings suggest that early metabolic changes, as a result from prenatal environmental influences, could affect long chain polyunsaturated fatty acid metabolism later in life. These results may contribute to explain the relationship between early nutrition and growth and later metabolic disorders as CVD.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalAtherosclerosis
Volume217
Issue number1
DOIs
Publication statusPublished - Jul 1 2011

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Keywords

  • Adolescents
  • Birth weight
  • HELENA study
  • Long chain polyunsaturated fatty acids
  • Phospholipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Labayen, I., Moreno, L. A., Ruiz, J. R., Ortega, F. B., Sjostrom, M., Huybrechts, I., Gonzalez-Gross, M., Spinneker, A., De Henauw, S., Manios, Y., Molnar, D., Leclercq, C., & Gottrand, F. (2011). Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. Atherosclerosis, 217(1), 286-291. https://doi.org/10.1016/j.atherosclerosis.2011.03.032