Associations between macronutrient intake and serum lipid profile depend on body fat in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

Silvia Bel-Serrat, Theodora Mouratidou, Inge Huybrechts, Idoia Labayen, Magdalena Cuenca-Garciá, Gonzalo Palacios, Christina Breidenassel, Dénes Molnár, Romana Roccaldo, Kurt Widhalm, Frederic Gottrand, Anthony Kafatos, Yannis Manios, Krishna Vyncke, Michael Sjöström, Lars Libuda, Sonia Gómez-Martínez, Luis A. Moreno

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5 Citations (Scopus)

Abstract

The present study aimed to investigate the relationships between macronutrient intake and serum lipid profile in adolescents from eight European cities participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) cross-sectional study (2006-7), and to assess the role of body fat-related variables in these associations. Weight, height, waist circumference, skinfold thicknesses, total cholesterol, HDL-cholesterol (HDL-C), LDL-cholesterol, TAG, apoB and apoA1 were measured in 454 adolescents (44 % boys) aged 12·5-17·5 years. Macronutrient intake (g/4180 kJ per d (1000 kcal per d)) was assessed using two non-consecutive 24 h dietary recalls. Associations were evaluated by multi-level analysis and adjusted for sex, age, maternal education, centre, sum of four skinfolds, moderate-to-vigorous physical activity, sedentary behaviours and diet quality index for adolescents. Carbohydrate intake was inversely associated with HDL-C (β =-0·189, P< 0·001). An inverse association was found between fat intake and TAG (β =-0·319, P< 0·001). Associations between macronutrient intake and serum lipids varied according to adiposity levels, i.e. an inverse association between carbohydrate intake and HDL-C was only observed in those adolescents with a higher waist:height ratio. As serum lipids and excess body fat are the major markers of CVD, these findings should be considered when developing strategies to prevent the risk of CVD among adolescents.

Original languageEnglish
Pages (from-to)2049-2059
Number of pages11
JournalBritish Journal of Nutrition
Volume112
Issue number12
DOIs
Publication statusPublished - Dec 28 2014

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Keywords

  • Adolescents
  • Body fat
  • Macronutrient intake
  • Serum lipids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Bel-Serrat, S., Mouratidou, T., Huybrechts, I., Labayen, I., Cuenca-Garciá, M., Palacios, G., Breidenassel, C., Molnár, D., Roccaldo, R., Widhalm, K., Gottrand, F., Kafatos, A., Manios, Y., Vyncke, K., Sjöström, M., Libuda, L., Gómez-Martínez, S., & Moreno, L. A. (2014). Associations between macronutrient intake and serum lipid profile depend on body fat in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. British Journal of Nutrition, 112(12), 2049-2059. https://doi.org/10.1017/S0007114514003183