Associations between interleukin-6 genetic polymorphisms and levels of autoantibodies to 60-kDa heat-shock proteins

Petra Kiszel, George Füst, Tanja Pessi, Mikko Hurme, Zoltán Prohászka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aims: Previously we reported an association between levels of anti-Hsp60 autoantibodies and interleukin-6 (IL-6) -174 SNP in Finnish population. The aim of this study was to investigate the same association in an independent population and to study four recently described SNP in IL-6. Materials and Methods: 313 healthy Hungarian subjects were recruited and genotyped for IL-6 -174(G→C), -9316(T→C), -1363(G→T), +1753(C→G), +2954(G→C). IgG antibodies to Hsp60 were measured by ELISA. LD between SNPs was computed by Haploview 3.2 software. Results: A strong association between IL-6-174 polymorphism and anti-Hsp60 autoantibody levels was observed. Carriers of -174 CC genotype had significantly lower levels of anti-Hsp60 (p = 0.0052). Eight haplotypes were observed with five SNP-s and autoantibody levels in individuals carrying the most common haplotype (containing allele C of -174) were significantly lower than in all other genotype combinations (p = 0.026). Conclusions: Allele C of -174 promoter polymorphism of the IL-6 gene was repeatedly shown to be associated with low anti-Hsp60 autoantibody levels. Strong linkage in the IL-6 gene was observed and the most frequent haplotype containing the -174 C allele was significantly associated with autoantibody levels. Since the -174 SNP of IL-6 is a functional polymorphism, our results indicate for a direct regulatory effect of IL-6 genotypes in the determination of autoantibody levels.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalHuman Heredity
Volume62
Issue number2
DOIs
Publication statusPublished - Nov 1 2006

Keywords

  • Anti-Hsp60 autoantibodies
  • Haplotype analysis
  • Haploview
  • Healthy population
  • Interleukin-6

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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