Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study

Vanessa Legry, Szilvia Bokor, Laurent Beghin, Myriam Galfo, Marcela Gonzalez-Gross, Denes Molnar, Luis A. Moreno, Philippe Amouyel, Jean Dallongeville, Aline Meirhaeghe

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Abstract

Objective: Genetic variability in the NR1H3 gene (encoding LXRα) and in several of its target genes is associated with serum HDL-cholesterol (HDL-C) concentrations. We sought to assess if these associations could be detected in adolescents. Methods: Thirty-nine polymorphisms in NR1H3, ABCA1, APOE, CETP, PLTP and LPL were analysed in the HELENA study (n= 1144 European adolescents). Results: The minor alleles of rs11039155 in NR1H3, rs2575879 in ABCA1, rs708272, rs17231506 and rs5882 in CETP and rs328 in LPL were associated with higher serum HDL-C concentrations (p≤ 0.0012). The minor alleles of rs12221497 in NR1H3, rs1800978 in ABCA1 and the APOE e{open}4 allele were associated with lower HDL-C concentrations (p≤ 0.01). The combined set of associated polymorphisms accounted for ∼6.6% of the variance in HDL-C. Conclusion: We report for the first time that polymorphisms in NR1H3 and its target genes ABCA1, APOE, CETP and LPL contribute to the genetic variance for HDL-C concentrations in adolescence.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalAtherosclerosis
Volume216
Issue number1
DOIs
Publication statusPublished - May 2011

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Keywords

  • ABCA1
  • Adolescents
  • Association study
  • HDL-cholesterol
  • LXR alpha
  • Lipid
  • Polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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