Association study of interferon-γ, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The increased production of proinflammatory mediators such as cytokines and prostaglandins may interact at multiple levels with neurodegeneration in Alzheimer disease (AD). This study was undertaken to evaluate the possible role of interferon-γ (IFN-γ) T+874A, cytoplasmic phospholipase A2 (cPLA2) BanI, and cyclooxygenase-2 (COX-2) G-765C polymorphisms in AD. Methods: The study included 237 probable patients with AD who met the diagnostic criteria of National Institute of Neurological and Communicative Disorders and Stroke-AD and Related Disorders Association, and 245 probands in the healthy comparison (HC) group. Results: No significant difference in mean age or in the distribution of genders between AD and HC groups was found. The COX-2 G/G genotype was significantly more frequent in the AD, when compared with the HC group. There was no significant correlation between IFN-γ or cPLA2 genotypes and AD. Conclusions: Our findings indicate that the COX-2 G/G genotype is associated with AD and support the involvement of COX-2 in AD etiology.

Original languageEnglish
Pages (from-to)983-987
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Cytosolic Phospholipases A2
Cyclooxygenase 2
Interferons
Alzheimer Disease
Genes
Phospholipases A2
Genotype
National Institute of Neurological Disorders and Stroke
Communication Disorders
Prostaglandins
Cytokines

Keywords

  • Alzheimer disease
  • cyclooxygenase-2
  • cytosolic phospholipase A2
  • Interferon-γ
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

@article{d5b152efa627402ba6990a9958cf5cfb,
title = "Association study of interferon-γ, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease",
abstract = "Objective: The increased production of proinflammatory mediators such as cytokines and prostaglandins may interact at multiple levels with neurodegeneration in Alzheimer disease (AD). This study was undertaken to evaluate the possible role of interferon-γ (IFN-γ) T+874A, cytoplasmic phospholipase A2 (cPLA2) BanI, and cyclooxygenase-2 (COX-2) G-765C polymorphisms in AD. Methods: The study included 237 probable patients with AD who met the diagnostic criteria of National Institute of Neurological and Communicative Disorders and Stroke-AD and Related Disorders Association, and 245 probands in the healthy comparison (HC) group. Results: No significant difference in mean age or in the distribution of genders between AD and HC groups was found. The COX-2 G/G genotype was significantly more frequent in the AD, when compared with the HC group. There was no significant correlation between IFN-γ or cPLA2 genotypes and AD. Conclusions: Our findings indicate that the COX-2 G/G genotype is associated with AD and support the involvement of COX-2 in AD etiology.",
keywords = "Alzheimer disease, cyclooxygenase-2, cytosolic phospholipase A2, Interferon-γ, single nucleotide polymorphism",
author = "{\'A}gnes Feh{\'e}r and A. Juh{\'a}sz and A. Riman{\'o}czy and J. K{\'a}lm{\'a}n and Z. Janka",
year = "2010",
month = "11",
doi = "10.1097/JGP.0b013e3181e70c05",
language = "English",
volume = "18",
pages = "983--987",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Association study of interferon-γ, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease

AU - Fehér, Ágnes

AU - Juhász, A.

AU - Rimanóczy, A.

AU - Kálmán, J.

AU - Janka, Z.

PY - 2010/11

Y1 - 2010/11

N2 - Objective: The increased production of proinflammatory mediators such as cytokines and prostaglandins may interact at multiple levels with neurodegeneration in Alzheimer disease (AD). This study was undertaken to evaluate the possible role of interferon-γ (IFN-γ) T+874A, cytoplasmic phospholipase A2 (cPLA2) BanI, and cyclooxygenase-2 (COX-2) G-765C polymorphisms in AD. Methods: The study included 237 probable patients with AD who met the diagnostic criteria of National Institute of Neurological and Communicative Disorders and Stroke-AD and Related Disorders Association, and 245 probands in the healthy comparison (HC) group. Results: No significant difference in mean age or in the distribution of genders between AD and HC groups was found. The COX-2 G/G genotype was significantly more frequent in the AD, when compared with the HC group. There was no significant correlation between IFN-γ or cPLA2 genotypes and AD. Conclusions: Our findings indicate that the COX-2 G/G genotype is associated with AD and support the involvement of COX-2 in AD etiology.

AB - Objective: The increased production of proinflammatory mediators such as cytokines and prostaglandins may interact at multiple levels with neurodegeneration in Alzheimer disease (AD). This study was undertaken to evaluate the possible role of interferon-γ (IFN-γ) T+874A, cytoplasmic phospholipase A2 (cPLA2) BanI, and cyclooxygenase-2 (COX-2) G-765C polymorphisms in AD. Methods: The study included 237 probable patients with AD who met the diagnostic criteria of National Institute of Neurological and Communicative Disorders and Stroke-AD and Related Disorders Association, and 245 probands in the healthy comparison (HC) group. Results: No significant difference in mean age or in the distribution of genders between AD and HC groups was found. The COX-2 G/G genotype was significantly more frequent in the AD, when compared with the HC group. There was no significant correlation between IFN-γ or cPLA2 genotypes and AD. Conclusions: Our findings indicate that the COX-2 G/G genotype is associated with AD and support the involvement of COX-2 in AD etiology.

KW - Alzheimer disease

KW - cyclooxygenase-2

KW - cytosolic phospholipase A2

KW - Interferon-γ

KW - single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=78149280715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149280715&partnerID=8YFLogxK

U2 - 10.1097/JGP.0b013e3181e70c05

DO - 10.1097/JGP.0b013e3181e70c05

M3 - Article

C2 - 20808133

AN - SCOPUS:78149280715

VL - 18

SP - 983

EP - 987

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

SN - 1064-7481

IS - 11

ER -