Association of young and advanced age of pregnant women with the risk of isolated congenital abnormalities in Hungary - A population-based case-matched control study

Gyula Csermely, Éva Susánszky, E. Czeizel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To analyze the possible association of maternal age with the risk of all congenital abnormalities (CAs) in a population-based large case-matched control data set. Methods: The Hungarian Case-Control Surveillance of Congenital Abnormalities included 21494 cases with isolated CA and their 34311 matched controls. First the distribution of maternal age groups in 24 CA-groups and their matched controls was compared. In the second step, young (19 years or less) and advanced (35 years or more) age groups were compared. Finally, the subgroups of neural-tube defects, congenital heart defects and abdominal wall's CA were evaluated separately. Results: A higher risk of gastroschisis, congenital heart defects, particularly left-sided obstructive defects, undescended testis and clubfoot was found in the youngest age group (19 years or less) of cases. The higher proportion of pregnant women with advanced age (i.e. 35 years or more) showed only a borderline excess in cases with clubfoot. The so-called U-shaped risk of maternal age distribution was found in cases with clubfoot and in the total group of isolated CAs. Conclusions: The maternal age is a contributing factor to the origin of some isolated CAs mainly in young pregnant women.

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Hungary
Case-Control Studies
Pregnant Women
Maternal Age
Clubfoot
Population
Congenital Heart Defects
Age Groups
Gastroschisis
Cryptorchidism
Neural Tube Defects
Age Distribution
Abdominal Wall
Research Design

Keywords

  • Clubfoot
  • Congenital abnormalities
  • Congenital heart defects
  • Gastroschisis
  • Maternal age
  • Population-based case-control study
  • Pregnancy
  • Undescended testis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

@article{a26232c82b2441af9336627b1ac1e881,
title = "Association of young and advanced age of pregnant women with the risk of isolated congenital abnormalities in Hungary - A population-based case-matched control study",
abstract = "Objective: To analyze the possible association of maternal age with the risk of all congenital abnormalities (CAs) in a population-based large case-matched control data set. Methods: The Hungarian Case-Control Surveillance of Congenital Abnormalities included 21494 cases with isolated CA and their 34311 matched controls. First the distribution of maternal age groups in 24 CA-groups and their matched controls was compared. In the second step, young (19 years or less) and advanced (35 years or more) age groups were compared. Finally, the subgroups of neural-tube defects, congenital heart defects and abdominal wall's CA were evaluated separately. Results: A higher risk of gastroschisis, congenital heart defects, particularly left-sided obstructive defects, undescended testis and clubfoot was found in the youngest age group (19 years or less) of cases. The higher proportion of pregnant women with advanced age (i.e. 35 years or more) showed only a borderline excess in cases with clubfoot. The so-called U-shaped risk of maternal age distribution was found in cases with clubfoot and in the total group of isolated CAs. Conclusions: The maternal age is a contributing factor to the origin of some isolated CAs mainly in young pregnant women.",
keywords = "Clubfoot, Congenital abnormalities, Congenital heart defects, Gastroschisis, Maternal age, Population-based case-control study, Pregnancy, Undescended testis",
author = "Gyula Csermely and {\'E}va Sus{\'a}nszky and E. Czeizel",
year = "2015",
month = "3",
day = "1",
doi = "10.3109/14767058.2014.918946",
language = "English",
volume = "28",
pages = "436--442",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Association of young and advanced age of pregnant women with the risk of isolated congenital abnormalities in Hungary - A population-based case-matched control study

AU - Csermely, Gyula

AU - Susánszky, Éva

AU - Czeizel, E.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Objective: To analyze the possible association of maternal age with the risk of all congenital abnormalities (CAs) in a population-based large case-matched control data set. Methods: The Hungarian Case-Control Surveillance of Congenital Abnormalities included 21494 cases with isolated CA and their 34311 matched controls. First the distribution of maternal age groups in 24 CA-groups and their matched controls was compared. In the second step, young (19 years or less) and advanced (35 years or more) age groups were compared. Finally, the subgroups of neural-tube defects, congenital heart defects and abdominal wall's CA were evaluated separately. Results: A higher risk of gastroschisis, congenital heart defects, particularly left-sided obstructive defects, undescended testis and clubfoot was found in the youngest age group (19 years or less) of cases. The higher proportion of pregnant women with advanced age (i.e. 35 years or more) showed only a borderline excess in cases with clubfoot. The so-called U-shaped risk of maternal age distribution was found in cases with clubfoot and in the total group of isolated CAs. Conclusions: The maternal age is a contributing factor to the origin of some isolated CAs mainly in young pregnant women.

AB - Objective: To analyze the possible association of maternal age with the risk of all congenital abnormalities (CAs) in a population-based large case-matched control data set. Methods: The Hungarian Case-Control Surveillance of Congenital Abnormalities included 21494 cases with isolated CA and their 34311 matched controls. First the distribution of maternal age groups in 24 CA-groups and their matched controls was compared. In the second step, young (19 years or less) and advanced (35 years or more) age groups were compared. Finally, the subgroups of neural-tube defects, congenital heart defects and abdominal wall's CA were evaluated separately. Results: A higher risk of gastroschisis, congenital heart defects, particularly left-sided obstructive defects, undescended testis and clubfoot was found in the youngest age group (19 years or less) of cases. The higher proportion of pregnant women with advanced age (i.e. 35 years or more) showed only a borderline excess in cases with clubfoot. The so-called U-shaped risk of maternal age distribution was found in cases with clubfoot and in the total group of isolated CAs. Conclusions: The maternal age is a contributing factor to the origin of some isolated CAs mainly in young pregnant women.

KW - Clubfoot

KW - Congenital abnormalities

KW - Congenital heart defects

KW - Gastroschisis

KW - Maternal age

KW - Population-based case-control study

KW - Pregnancy

KW - Undescended testis

UR - http://www.scopus.com/inward/record.url?scp=84924386781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924386781&partnerID=8YFLogxK

U2 - 10.3109/14767058.2014.918946

DO - 10.3109/14767058.2014.918946

M3 - Article

C2 - 24766076

AN - SCOPUS:84924386781

VL - 28

SP - 436

EP - 442

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 4

ER -