Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia

Sibylle G. Schwab, Stephanie Mondabon, Michael Knapp, Margot Albus, Joachim Hallmayer, Margitta Borrmann-Hassenbach, M. Trixler, Magdalena Groß, Thomas G. Schulze, Marcella Rietschel, Bernard Lerer, Wolfgang Maier, Dieter B. Wildenauer

Research output: Contribution to journalArticle

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Abstract

Background: Tumor necrosis factor alpha (TNFα), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFα gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]. Methods: Association of the -G308A TNFα gene and the lymphotoxin alpha (LTα)+A252G gene polymorphisms with schizophrenia was studied in 79 sib pair families with linkage in the MHC region and in 128 trio families using the transmission disequilibrium test (TDT). Results: Weak association of the common G allele was detected for TNFα -G308A in both samples independently with borderline significance in the sib pair families (0.064) and with a nominally significant value of P=0.022 in the trio families. Combining both samples produced P=0.003, while LTα+A252G, located approximately 2-3 kb distally, revealed P=0.03 and the two locus haplotype yielded a P value of 0.001. Conclusion: Our data suggests association of the common G allele of the -G308A TNFα gene polymorphism with schizophrenia in a sample of 207 families. However, linkage disequilibrium with a different allele of the TNFα gene or another gene in the MHC region cannot be excluded.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalSchizophrenia Research
Volume65
Issue number1
DOIs
Publication statusPublished - Dec 1 2003

Fingerprint

Schizophrenia
Tumor Necrosis Factor-alpha
Lymphotoxin-alpha
Major Histocompatibility Complex
Alleles
Genes
Linkage Disequilibrium
Haplotypes
Psychiatry
Cytokines

Keywords

  • Association
  • Cytokines
  • Linkage disequilibrium
  • LTα
  • Schizophrenia
  • TNFα

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Schwab, S. G., Mondabon, S., Knapp, M., Albus, M., Hallmayer, J., Borrmann-Hassenbach, M., ... Wildenauer, D. B. (2003). Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia. Schizophrenia Research, 65(1), 19-25. https://doi.org/10.1016/S0920-9964(02)00534-0

Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia. / Schwab, Sibylle G.; Mondabon, Stephanie; Knapp, Michael; Albus, Margot; Hallmayer, Joachim; Borrmann-Hassenbach, Margitta; Trixler, M.; Groß, Magdalena; Schulze, Thomas G.; Rietschel, Marcella; Lerer, Bernard; Maier, Wolfgang; Wildenauer, Dieter B.

In: Schizophrenia Research, Vol. 65, No. 1, 01.12.2003, p. 19-25.

Research output: Contribution to journalArticle

Schwab, SG, Mondabon, S, Knapp, M, Albus, M, Hallmayer, J, Borrmann-Hassenbach, M, Trixler, M, Groß, M, Schulze, TG, Rietschel, M, Lerer, B, Maier, W & Wildenauer, DB 2003, 'Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia', Schizophrenia Research, vol. 65, no. 1, pp. 19-25. https://doi.org/10.1016/S0920-9964(02)00534-0
Schwab SG, Mondabon S, Knapp M, Albus M, Hallmayer J, Borrmann-Hassenbach M et al. Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia. Schizophrenia Research. 2003 Dec 1;65(1):19-25. https://doi.org/10.1016/S0920-9964(02)00534-0
Schwab, Sibylle G. ; Mondabon, Stephanie ; Knapp, Michael ; Albus, Margot ; Hallmayer, Joachim ; Borrmann-Hassenbach, Margitta ; Trixler, M. ; Groß, Magdalena ; Schulze, Thomas G. ; Rietschel, Marcella ; Lerer, Bernard ; Maier, Wolfgang ; Wildenauer, Dieter B. / Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia. In: Schizophrenia Research. 2003 ; Vol. 65, No. 1. pp. 19-25.
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AU - Schwab, Sibylle G.

AU - Mondabon, Stephanie

AU - Knapp, Michael

AU - Albus, Margot

AU - Hallmayer, Joachim

AU - Borrmann-Hassenbach, Margitta

AU - Trixler, M.

AU - Groß, Magdalena

AU - Schulze, Thomas G.

AU - Rietschel, Marcella

AU - Lerer, Bernard

AU - Maier, Wolfgang

AU - Wildenauer, Dieter B.

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N2 - Background: Tumor necrosis factor alpha (TNFα), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFα gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]. Methods: Association of the -G308A TNFα gene and the lymphotoxin alpha (LTα)+A252G gene polymorphisms with schizophrenia was studied in 79 sib pair families with linkage in the MHC region and in 128 trio families using the transmission disequilibrium test (TDT). Results: Weak association of the common G allele was detected for TNFα -G308A in both samples independently with borderline significance in the sib pair families (0.064) and with a nominally significant value of P=0.022 in the trio families. Combining both samples produced P=0.003, while LTα+A252G, located approximately 2-3 kb distally, revealed P=0.03 and the two locus haplotype yielded a P value of 0.001. Conclusion: Our data suggests association of the common G allele of the -G308A TNFα gene polymorphism with schizophrenia in a sample of 207 families. However, linkage disequilibrium with a different allele of the TNFα gene or another gene in the MHC region cannot be excluded.

AB - Background: Tumor necrosis factor alpha (TNFα), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFα gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]. Methods: Association of the -G308A TNFα gene and the lymphotoxin alpha (LTα)+A252G gene polymorphisms with schizophrenia was studied in 79 sib pair families with linkage in the MHC region and in 128 trio families using the transmission disequilibrium test (TDT). Results: Weak association of the common G allele was detected for TNFα -G308A in both samples independently with borderline significance in the sib pair families (0.064) and with a nominally significant value of P=0.022 in the trio families. Combining both samples produced P=0.003, while LTα+A252G, located approximately 2-3 kb distally, revealed P=0.03 and the two locus haplotype yielded a P value of 0.001. Conclusion: Our data suggests association of the common G allele of the -G308A TNFα gene polymorphism with schizophrenia in a sample of 207 families. However, linkage disequilibrium with a different allele of the TNFα gene or another gene in the MHC region cannot be excluded.

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