Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder

Andrea Sarosi, X. Gonda, Gabriella Balogh, Eszter Domotor, A. Székely, Krisztina Hejjas, M. Sasvári, G. Faludi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression. Methods: 71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance. Results: We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele. Conclusion: Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.

Original languageEnglish
Pages (from-to)1667-1672
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number7
DOIs
Publication statusPublished - Oct 1 2008

Fingerprint

Endophenotypes
Serotonin Plasma Membrane Transport Proteins
Major Depressive Disorder
Alleles
Genes
Depression
Verbal Learning
Short-Term Memory
Genotype

Keywords

  • Endophenotype
  • Major depression
  • Neurocognitive performance
  • Polymorphism
  • Serotonin transporter gene
  • STin2

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder. / Sarosi, Andrea; Gonda, X.; Balogh, Gabriella; Domotor, Eszter; Székely, A.; Hejjas, Krisztina; Sasvári, M.; Faludi, G.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 7, 01.10.2008, p. 1667-1672.

Research output: Contribution to journalArticle

@article{f8e64fd31aa741d4b5a3ed012b751e15,
title = "Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder",
abstract = "Background: The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression. Methods: 71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance. Results: We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele. Conclusion: Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.",
keywords = "Endophenotype, Major depression, Neurocognitive performance, Polymorphism, Serotonin transporter gene, STin2",
author = "Andrea Sarosi and X. Gonda and Gabriella Balogh and Eszter Domotor and A. Sz{\'e}kely and Krisztina Hejjas and M. Sasv{\'a}ri and G. Faludi",
year = "2008",
month = "10",
day = "1",
doi = "10.1016/j.pnpbp.2008.06.014",
language = "English",
volume = "32",
pages = "1667--1672",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder

AU - Sarosi, Andrea

AU - Gonda, X.

AU - Balogh, Gabriella

AU - Domotor, Eszter

AU - Székely, A.

AU - Hejjas, Krisztina

AU - Sasvári, M.

AU - Faludi, G.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Background: The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression. Methods: 71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance. Results: We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele. Conclusion: Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.

AB - Background: The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression. Methods: 71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance. Results: We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele. Conclusion: Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.

KW - Endophenotype

KW - Major depression

KW - Neurocognitive performance

KW - Polymorphism

KW - Serotonin transporter gene

KW - STin2

UR - http://www.scopus.com/inward/record.url?scp=51349091819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51349091819&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2008.06.014

DO - 10.1016/j.pnpbp.2008.06.014

M3 - Article

C2 - 18647635

AN - SCOPUS:51349091819

VL - 32

SP - 1667

EP - 1672

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 7

ER -