Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

Sean E. Egan, Barton W. Giddings, Mary W. Brooks, L. Buday, Andrew M. Sizeland, Robert A. Weinberg

Research output: Contribution to journalArticle

955 Citations (Scopus)

Abstract

The proteins Grb2-Sem-5, She and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, She. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalNature
Volume363
Issue number6424
Publication statusPublished - May 6 1993

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ras Proteins
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Signal Transduction
src Homology Domains
Drosophila
Cell Differentiation
Rodentia
Carrier Proteins
Fibroblasts
Ligands
Growth
Proteins
Ectopic Gene Expression

ASJC Scopus subject areas

  • General

Cite this

Egan, S. E., Giddings, B. W., Brooks, M. W., Buday, L., Sizeland, A. M., & Weinberg, R. A. (1993). Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature, 363(6424), 45-51.

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. / Egan, Sean E.; Giddings, Barton W.; Brooks, Mary W.; Buday, L.; Sizeland, Andrew M.; Weinberg, Robert A.

In: Nature, Vol. 363, No. 6424, 06.05.1993, p. 45-51.

Research output: Contribution to journalArticle

Egan, SE, Giddings, BW, Brooks, MW, Buday, L, Sizeland, AM & Weinberg, RA 1993, 'Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation', Nature, vol. 363, no. 6424, pp. 45-51.
Egan, Sean E. ; Giddings, Barton W. ; Brooks, Mary W. ; Buday, L. ; Sizeland, Andrew M. ; Weinberg, Robert A. / Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. In: Nature. 1993 ; Vol. 363, No. 6424. pp. 45-51.
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