Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex

Pablo Sandro Carvalho Santos, G. Füst, Z. Prohászka, Armin Volz, Roger Horton, Marcos Miretti, Chack Yung Yu, Stephan Beck, Barbara Uchanska-Ziegler, Andreas Ziegler

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the extended HLA complex might be responsible for the observed association, by genotyping a cohort of Hungarian women in which the mentioned association had been found. One hundred and eighty HLA haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed in silico to identify single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene (rs3749971T) was found to be linked to the A1-B8-DR3 haplotype. This polymorphism leads to a 97Thr→Ile exchange that affects a putative ligand binding region of the OR12D3 protein. Smoking was found to be associated in the Hungarian cohort with the rs3749971T allele (p=1.05×10-2), with higher significance than with A1-B8-DR3 (p=2.38×10-2). Our results link smoking to a distinct OR allele, and demonstrate that the rs3749971T polymorphism is associated with the HLA haplotype-dependent differential recognition of cigarette smoke components, at least among Caucasian women.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalGenetic Testing
Volume12
Issue number4
DOIs
Publication statusPublished - Dec 1 2008

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Odorant Receptors
Major Histocompatibility Complex
Haplotypes
Smoking
Alleles
HLA Antigens
Single Nucleotide Polymorphism
Linkage Disequilibrium
Smoke
Tobacco Products
Computer Simulation
Genes
Ligands

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex. / Santos, Pablo Sandro Carvalho; Füst, G.; Prohászka, Z.; Volz, Armin; Horton, Roger; Miretti, Marcos; Yu, Chack Yung; Beck, Stephan; Uchanska-Ziegler, Barbara; Ziegler, Andreas.

In: Genetic Testing, Vol. 12, No. 4, 01.12.2008, p. 481-486.

Research output: Contribution to journalArticle

Santos, PSC, Füst, G, Prohászka, Z, Volz, A, Horton, R, Miretti, M, Yu, CY, Beck, S, Uchanska-Ziegler, B & Ziegler, A 2008, 'Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex', Genetic Testing, vol. 12, no. 4, pp. 481-486. https://doi.org/10.1089/gte.2008.0029
Santos, Pablo Sandro Carvalho ; Füst, G. ; Prohászka, Z. ; Volz, Armin ; Horton, Roger ; Miretti, Marcos ; Yu, Chack Yung ; Beck, Stephan ; Uchanska-Ziegler, Barbara ; Ziegler, Andreas. / Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex. In: Genetic Testing. 2008 ; Vol. 12, No. 4. pp. 481-486.
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