Association of serum phosphorus level with anemia in kidney transplant recipients

Csaba P. Kovesdy, I. Mucsi, Maria E. Czira, Anna Rudas, Akos Ujszaszi, L. Rosivall, S. Joseph Kim, Myles Wolf, M. Molnár

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Anemia and mineral and bone disorders (MBD) are both important and common complications in kidney transplant recipients. Studies in patients with chronic kidney disease indicated a possible independent association of higher serum phosphorus with anemia, but similar associations have not been examined in kidney transplant recipients. We hypothesized that higher serum phosphorus is associated with anemia independent of other components of MBD. Methods: We examined the association of serum phosphorus with hemoglobin level and the prevalence of anemia in a prevalent cohort of 992 kidney transplant recipients in a single outpatient transplant center. Associations were examined in linear and logistic regression models with adjustment for demographic and comorbid conditions for various known risk factors of anemia, including measures of iron deficiency, inflammation, and components of MBD including serum levels of 25(OH) vitamin D, parathyroid hormone, and fibroblast growth factor 23. Results: In multivariable adjusted regression models, a 1 standard deviation (0.8 mg/dL) higher serum phosphorus level was associated with 0.26 g/dL lower blood hemoglobin concentration (95% confidence intervals -0.36 to -0.15, P

Original languageEnglish
Pages (from-to)875-882
Number of pages8
JournalTransplantation
Volume91
Issue number8
DOIs
Publication statusPublished - Apr 27 2011

Fingerprint

Phosphorus
Anemia
Kidney
Minerals
Serum
Bone and Bones
Hemoglobins
Logistic Models
Parathyroid Hormone
Chronic Renal Insufficiency
Vitamin D
Linear Models
Outpatients
Iron
Demography
Transplant Recipients
Confidence Intervals
Inflammation
Transplants

Keywords

  • Anemia
  • Hemoglobin
  • Kidney transplant
  • Serum phosphorus

ASJC Scopus subject areas

  • Transplantation

Cite this

Association of serum phosphorus level with anemia in kidney transplant recipients. / Kovesdy, Csaba P.; Mucsi, I.; Czira, Maria E.; Rudas, Anna; Ujszaszi, Akos; Rosivall, L.; Kim, S. Joseph; Wolf, Myles; Molnár, M.

In: Transplantation, Vol. 91, No. 8, 27.04.2011, p. 875-882.

Research output: Contribution to journalArticle

Kovesdy, Csaba P. ; Mucsi, I. ; Czira, Maria E. ; Rudas, Anna ; Ujszaszi, Akos ; Rosivall, L. ; Kim, S. Joseph ; Wolf, Myles ; Molnár, M. / Association of serum phosphorus level with anemia in kidney transplant recipients. In: Transplantation. 2011 ; Vol. 91, No. 8. pp. 875-882.
@article{c3035b0915bd42bf9319c31f8fa620a4,
title = "Association of serum phosphorus level with anemia in kidney transplant recipients",
abstract = "Background: Anemia and mineral and bone disorders (MBD) are both important and common complications in kidney transplant recipients. Studies in patients with chronic kidney disease indicated a possible independent association of higher serum phosphorus with anemia, but similar associations have not been examined in kidney transplant recipients. We hypothesized that higher serum phosphorus is associated with anemia independent of other components of MBD. Methods: We examined the association of serum phosphorus with hemoglobin level and the prevalence of anemia in a prevalent cohort of 992 kidney transplant recipients in a single outpatient transplant center. Associations were examined in linear and logistic regression models with adjustment for demographic and comorbid conditions for various known risk factors of anemia, including measures of iron deficiency, inflammation, and components of MBD including serum levels of 25(OH) vitamin D, parathyroid hormone, and fibroblast growth factor 23. Results: In multivariable adjusted regression models, a 1 standard deviation (0.8 mg/dL) higher serum phosphorus level was associated with 0.26 g/dL lower blood hemoglobin concentration (95{\%} confidence intervals -0.36 to -0.15, P",
keywords = "Anemia, Hemoglobin, Kidney transplant, Serum phosphorus",
author = "Kovesdy, {Csaba P.} and I. Mucsi and Czira, {Maria E.} and Anna Rudas and Akos Ujszaszi and L. Rosivall and Kim, {S. Joseph} and Myles Wolf and M. Moln{\'a}r",
year = "2011",
month = "4",
day = "27",
doi = "10.1097/TP.0b013e3182111edf",
language = "English",
volume = "91",
pages = "875--882",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Association of serum phosphorus level with anemia in kidney transplant recipients

AU - Kovesdy, Csaba P.

AU - Mucsi, I.

AU - Czira, Maria E.

AU - Rudas, Anna

AU - Ujszaszi, Akos

AU - Rosivall, L.

AU - Kim, S. Joseph

AU - Wolf, Myles

AU - Molnár, M.

PY - 2011/4/27

Y1 - 2011/4/27

N2 - Background: Anemia and mineral and bone disorders (MBD) are both important and common complications in kidney transplant recipients. Studies in patients with chronic kidney disease indicated a possible independent association of higher serum phosphorus with anemia, but similar associations have not been examined in kidney transplant recipients. We hypothesized that higher serum phosphorus is associated with anemia independent of other components of MBD. Methods: We examined the association of serum phosphorus with hemoglobin level and the prevalence of anemia in a prevalent cohort of 992 kidney transplant recipients in a single outpatient transplant center. Associations were examined in linear and logistic regression models with adjustment for demographic and comorbid conditions for various known risk factors of anemia, including measures of iron deficiency, inflammation, and components of MBD including serum levels of 25(OH) vitamin D, parathyroid hormone, and fibroblast growth factor 23. Results: In multivariable adjusted regression models, a 1 standard deviation (0.8 mg/dL) higher serum phosphorus level was associated with 0.26 g/dL lower blood hemoglobin concentration (95% confidence intervals -0.36 to -0.15, P

AB - Background: Anemia and mineral and bone disorders (MBD) are both important and common complications in kidney transplant recipients. Studies in patients with chronic kidney disease indicated a possible independent association of higher serum phosphorus with anemia, but similar associations have not been examined in kidney transplant recipients. We hypothesized that higher serum phosphorus is associated with anemia independent of other components of MBD. Methods: We examined the association of serum phosphorus with hemoglobin level and the prevalence of anemia in a prevalent cohort of 992 kidney transplant recipients in a single outpatient transplant center. Associations were examined in linear and logistic regression models with adjustment for demographic and comorbid conditions for various known risk factors of anemia, including measures of iron deficiency, inflammation, and components of MBD including serum levels of 25(OH) vitamin D, parathyroid hormone, and fibroblast growth factor 23. Results: In multivariable adjusted regression models, a 1 standard deviation (0.8 mg/dL) higher serum phosphorus level was associated with 0.26 g/dL lower blood hemoglobin concentration (95% confidence intervals -0.36 to -0.15, P

KW - Anemia

KW - Hemoglobin

KW - Kidney transplant

KW - Serum phosphorus

UR - http://www.scopus.com/inward/record.url?scp=79954708035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954708035&partnerID=8YFLogxK

U2 - 10.1097/TP.0b013e3182111edf

DO - 10.1097/TP.0b013e3182111edf

M3 - Article

C2 - 21358369

AN - SCOPUS:79954708035

VL - 91

SP - 875

EP - 882

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 8

ER -