Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population

Balazs Halmos, F. Szalay, Tamas Cserniczky, Elemer Nemesanszky, P. Lakatos, Stefan Barlage, Gerd Schmitz, Laszlo Romics, A. Császár

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We sought to determine the distribution of vitamin D receptor genotypes defined by the BsmI polymorphism and to investigate their association with bone mineral density in patients with primary biliary cirrhosis. Vitamin D receptor genotype and bone mineral density at the lumbar spine was determined in 31 female Hungarian patients with primary biliary cirrhosis and 51 age- matched healthy female controls. The genotype frequency (BB: 45%, Bb: 32%, bb: 22%) of the patients was significantly different from the control group (P = 0.01) due to an overrepresentation of the BB genotype. There was an apparent trend, not reaching statistical significance, for a lower bone mineral density in both the patient and control groups carrying a B allele. In conclusion, we found a strikingly high frequency of the BB genotype in patients with primary biliary cirrhosis, which raises questions about hormonal influences on the development of primary biliary cirrhosis.

Original languageEnglish
Pages (from-to)1091-1095
Number of pages5
JournalDigestive Diseases and Sciences
Volume45
Issue number6
DOIs
Publication statusPublished - 2000

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Calcitriol Receptors
Biliary Liver Cirrhosis
Genotype
Bone Density
Population
Control Groups
Spine
Alleles

Keywords

  • Autoimmunity
  • Bone mineral density
  • Genotypes
  • Primary biliary cirrhosis
  • Vitamin D receptor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population. / Halmos, Balazs; Szalay, F.; Cserniczky, Tamas; Nemesanszky, Elemer; Lakatos, P.; Barlage, Stefan; Schmitz, Gerd; Romics, Laszlo; Császár, A.

In: Digestive Diseases and Sciences, Vol. 45, No. 6, 2000, p. 1091-1095.

Research output: Contribution to journalArticle

Halmos, Balazs ; Szalay, F. ; Cserniczky, Tamas ; Nemesanszky, Elemer ; Lakatos, P. ; Barlage, Stefan ; Schmitz, Gerd ; Romics, Laszlo ; Császár, A. / Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population. In: Digestive Diseases and Sciences. 2000 ; Vol. 45, No. 6. pp. 1091-1095.
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